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Anti-cancer cytotoxic effects of multiwalled carbon nanotubes

Abstract: Recent research has opened new alternatives to traditional chemotherapy treatments using nanomaterials as cytotoxic agents. Anti-cancer nanomedicines do not require specific target sites on key proteins or genes to kill cancer cells and have radically different mechanisms to interact with the living matter. Among 1D nanomaterials, multiwalled carbon nanotubes (MWCNTs) have the intrinsic ability to bind tubulin and interfere with microtubule dynamics, mimicking the effect of traditional cytotoxic microtubule-binding agents such as paclitaxel (taxol®). Here, we review the cytotoxic properties of MWCNTs and show a direct pro-apoptotic effect of these nanomaterials in vitro in different cancer cell lines and tumor cells obtained from surgical specimens. Understanding the bio-synthetic relationship between MWCNTs and microtubules could serve to improve these nanomaterials to be used as broad spectrum antineoplastic agents in combination to traditional microtubule-binding treatments, thus avoiding drug resistance mechanisms in cancer cells.

 Fuente: Current Pharmaceutical Design, 2015, 21, 1920-1929

Editorial: Bentham Science Publishers

 Año de publicación: 2015

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.2174/1381612821666150302144101

ISSN: 1381-6128,1873-4286

Proyecto español: Spanish MINECO Project Refs, PI13/01074 (AES 2013), MAT2012-38664-C02-01, RD12/0036/0022