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The Multiple Faces of MNT and Its Role as a MYC Modulator

Abstract: MNT is a crucial modulator of MYC, controls several cellular functions, and is activated in most human cancers. It is the largest, most divergent, and most ubiquitously expressed protein of the MXD family. MNT was first described as a MYC antagonist and tumor suppressor. Indeed, 10% of human tumors present deletions of one MNT allele. However, some reports show that MNT functions in cooperation with MYC by maintaining cell proliferation, promoting tumor cell survival, and supporting MYC-driven tumorigenesis in cellular and animal models. Although MAX was originally considered MNT?s obligate partner, our recent findings demonstrate that MNT also works independently. MNT forms homodimers and interacts with proteins both outside and inside of the proximal MYC network. These complexes are involved in a wide array of cellular processes, from transcriptional repression via SIN3 to the modulation of metabolism through MLX as well as immunity and apoptosis via REL. In this review, we discuss the present knowledge of MNT with a special focus on its interactome, which sheds light on the complex and essential role of MNT in cell biology.

 Fuente: Cancers (Basel) . 2021 Sep 18;13(18):4682

Editorial: MDPI

 Año de publicación: 2021

Nº de páginas: 16

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/cancers13184682

ISSN: 2072-6694

Proyecto español: SAF2017-88026-R

Url de la publicación: https://doi.org/10.3390/cancers13184682