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Abstract: This study analyzes the association between serum
uric acid levels and heel quantitative ultrasound (QUS) parameters
in men aged 50 or more from the Camargo cohort. We
found that higher serum uric acid levels are positively associated
with all QUS measurements, suggesting a better bone
quality in men with elevated serum uric acid values.
Introduction Higher serumuric acid concentrations have been
associated with higher bone mineral density and lower prevalence
of fractures. However, there are no studies that have
assessed the bone quality properties in Caucasians.
Therefore, we have analyzed the association between quantitative
ultrasound (QUS) and serum uric acid levels in adult
men from a population-based cohort.
Methods A total of 868men older than 50were recruited from
a larger cohort (Camargo Cohort) after excluding those with
any known condition or drug treatment with a possible influence
on bone metabolism, or those with a previous diagnosis
of gout or taking hipouricemic agents. Bone turnover markers
(PINP and CTX), 25OH-vitamin D and PTH levels were measured
by electrochemiluminiscence. BMD was determined by
DXA, and heel QUS with a gel-coupled device.
Results Lumbar, femoral neck and total hip BMD was significantly
higher in men with higher serum uric acid levels. QUS
parameters were also significantly higher in men with high
uric acid levels than those with lower values, and increased
continuously across quartiles after adjustment for confounding
variables. In multiple regression analysis, serum uric acid
was significantly associated with all QUS parameters. Finally,
men with serum acid levels above median showed higher
values in all the QUS parameters than men with lower values.
Conclusions Higher serum uric acid levels in men older than
50 years are positively associated with QUS parameters.
These data might suggest a better bone quality in men with
elevated serum uric acid values.
Fuente: Osteoporos Int. 2015 Jul; 26(7):1989-95
Editorial: Springer London
Fecha de publicación: 01/07/2015
Nº de páginas: 7
Tipo de publicación: Artículo de Revista
JOSE LUIS HERNANDEZ HERNANDEZ
JESUS MARIA HERMOGENES GONZALEZ MACIAS
JOSE MANUEL OLMOS MARTINEZ