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COVID-19 mRNA Based Vaccine Immune-Response Assessment in Nursing Home Residents for Public Health Decision

Abstract: Nursing home residents (NHR) have been targeted as a vaccination priority due to their higher risk of worse outcome after COVID-19 infection. The mRNA-based vaccine BTN2b2 was first approved in Europe for NHRs. The assessment of the specific vaccine immune response (both humoral and cellular) at long term in NHRs has not been addressed yet. A representative sample of 624 NHR subjects in Northern region of Spain was studied to assess immune response against full vaccination with BTN2b2. The anti-S1 antibody levels and specific T cells were measured at two and six months after vaccination. 24.4% of NHR had a previous infection prior to vaccination. The remaining NHR were included in the full vaccination assessment group (FVA). After two months, a 94.9% of the FVA presented anti-S1 antibodies, whereas those seronegative without specific cellular response were 2.54%. At long-term, the frequency of NHR within the FVA group with anti-S1 antibodies at six months were 88.12% and the seronegative subjects without specific cellular response was 8.07%. The cellular immune assays complement the humoral test in the immune vaccine response assessment. Therefore, the cellular immune assessment in NHRs allows for the fine tuning of those seronegative subjects with potential competent immune responses against the vaccine.

 Fuente: Vaccines 2021, 9(12), 1429

Editorial: MDPI

 Fecha de publicación: 02/12/2021

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/vaccines9121429

ISSN: 2076-393X

Url de la publicación: https://www.mdpi.com/2076-393X/9/12/1429

Autores/as

SAN SEGUNDO, DAVID

COMINS-BOO, ALEJANDRA

LAMADRID-PEROJO, PATRICIA

IRURE-VENTURA, JUAN

WALLMAN, REINHARD

CALVO-MONTES, JORGE

MÉNDEZ-LEGAZA, JOSÉ MANUEL

BAAMONDE-CALZADA, CARMELA

SÁNCHEZ-MOLINA, ISABEL

LECUE-MARTÍNEZ, MARINA

VENTISCA-PÉREZ, SILVIA

BATLLE-LÓPEZ, ANA