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Abstract: No differences in either bone mineral density or
serum 25OHD levels have been found between 205 women
with fibromyalgia (both pre- and postmenopausal) and their
controls. However, a lack of the expected 25OHD summer
rise was observed in patients.
Introduction Contradictory data have been published regarding
a possible association between fibromyalgia and
osteoporosis or hypovitaminosis D. Most studies, however,
have been performed in small size samples and have excluded
postmenopausal women. We decided to study this association
in a larger sample of fibromyalgia patients including
both pre- and postmenopausal women.
Methods Two hundred five patients were recruited from a
clinic specializing in fibromyalgia and 205 healthy controls
were enrolled from the census of a Primary Care Center.
Controls were matched with patients by age and the time of
the year they were included in the study. Bone mineral
density (BMD) was measured by DXA. Serum 25OHD,
iPTH, P1NP, and CTX were also determined.
Results BMD was similar in both groups (lumbar spine,
0.971±0.146 g/cm2 in patients and 0.970±0.132 g/cm2 in controls;
femoral neck, 0.780±0.122 g/cm2 and 0.785±0.117 g/cm2,
respectively). 25OHD levels were also similar: 23.0±9.5 ng/ml
and 24.1±9.6 ng/ml. However, while controls showed the usual
summer rise in 25OHD, fibromyalgia patients did not. PTH did
not showseasonal changes, but on average was higher in patients
(51 pg/ml vs. 48 pg/ml; p=0.034). P1NP or CTX were similar in
Conclusions No differences in BMD were found between
patients and controls. As for 25OHD, a lack of its expected
summer rise was observed. It is doubtful whether this has
any homeostatic consequence. We consider that the association
reported in other studies is merely circumstantial, and
not due to the intrinsic characteristics of these disorders.
Fuente: Osteoporos Int. 2014 Feb; 25(2):525-33
Editorial: Springer London
Fecha de publicación: 01/02/2014
Nº de páginas: 9
Tipo de publicación: Artículo de Revista
MARIA DEL CARMEN VALERO DIAZ DE LAMADRID
JOSE MANUEL OLMOS MARTINEZ
JESUS CASTILLO OBESO
JOSE LUIS HERNANDEZ HERNANDEZ
JESUS MARIA HERMOGENES GONZALEZ MACIAS