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 Detalle_Publicacion

Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage

Abstract: Primary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt identification to start the most effective treatment for this ultra-high-risk disease. The aim of this position paper is to revisit the diagnosis of PCL according to the presence of circulating plasma cells in patients otherwise meeting diagnostic criteria of multiple myeloma. We could identify two retrospective series where the question about what number of circulating plasma cells in peripheral blood should be used for defining PCL. The presence of ?5% circulating plasma cells in patients with MM had a similar adverse prognostic impact as the previously defined PCL. Therefore, PCL should be defined by the presence of 5% or more circulating plasma cells in peripheral blood smears in patients otherwise diagnosed with symptomatic multiple myeloma.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Blood Cancer J . 2021 Dec 2;11(12):192

Editorial: Nature Pub. Group

 Año de publicación: 2021

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s41408-021-00587-0

ISSN: 2044-5385

Url de la publicación: https://www.doi.org/10.1038/s41408-021-00587-0

Autores/as

FERNÁNDEZ DE LARREA, CARLOS

KYLE, ROBERT

ROSIÑOL, LAURA

PAIVA, BRUNO

ENGELHARDT, MONIKA

USMANI, SAAD

CAERS, JO

GONSALVES, WILSON

SCHJESVOLD, FREDRIK

MERLINI, GIAMPAOLO

GARDERET, LAURENT

MOREAU, PHILIPPE

SONNEVELD, PIETER

BADROS, ASHRAF

GAHRTON, GÖSTA

GOLDSCHMIDT, HARTMUT

TUCHMAN, SASCHA

EINSELE, HERMANN