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Evaluation of serum omentin-1 and apelin concentrations in patients with hidradenitis suppurativa

Abstract: Introduction: Recent studies suggest a role of adipokines in the pathogenesis of hidradenitis suppurativa (HS). Omentin-1 and apelin are two recently identified adipokines that have been involved in the regulation of metabolic and inflammatory responses. Aim: To investigate serum omentin-1 and apelin levels in patients with HS and to assess their associations with metabolic parameters, disease severity and HS risk. Material and methods: This case-control study included 139 non-diabetic individuals (78 HS patients and 61 ageand sex-matched controls). Serum concentrations of omentin-1 and apelin and the homeostasis model assessment of insulin resistance (HOMA-IR) were measured in all participants. Results: Serum omentin-1 concentrations were significantly higher in HS patients compared to controls, whereas apelin serum levels did not significantly differ between both groups. These differences in omentin-1 concentrations remained significant even after adjusting for age, sex, and body mass index (BMI). The results of logistic regression analysis showed that increased omentin-1 plasma levels were an independent risk factor for HS. However, we found no association between serum levels of both omentin-1 and apelin with HS severity. Conclusions: Our results show that patients with HS have raised omentin-1 serum levels, which are associated with HS risk.

 Fuente: Postepy Dermatol Alergol . 2021 Jun;38(3):450-454

Editorial: Termedia

 Año de publicación: 2021

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

 DOI: 10.5114/ada.2021.107932

ISSN: 1642-395X,2299-0046

Url de la publicación: https://doi.org/10.5114/ada.2021.107932

Autores/as

JAVIER GONZALO OCEJO VIÑALS

MATA, CRISTINA

DÍAZ, DIEGO

GUIRAL, SANDRA

PORTILLA, VIRGINIA

ALFONSO FERNANDO CORRALES MARTINEZ

RICARDO BLANCO ALONSO