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Subclinical atherosclerotic disease in ankylosing spondylitis and non-radiographic axial spondyloarthritis. A multicenter study on 806 patients

Abstract: Objectives: To compare the atherosclerosis disease burden between ankylosing spondylitis (AS) and non-radiographic (nr) axial spondyloarthritis (axSpA) and establish a model that allows to identify high-cardiovascular (CV) risk in axial spondyloarthritis patients. Methods: Cross-sectional study from the AtheSpAin cohort, a Spanish multicenter cohort aimed to study atherosclerosis in axSpA. Carotid ultrasound (US) was performed to determine the carotid intima-media wall thickness (cIMT) and detect the presence of carotid plaques. The European cardiovascular disease risk assessment model, the Systematic COronary Risk Evaluation (SCORE), was also applied. Results: A set of 639 patients with AS and 167 patients with nr-axSpA without history of CV events were recruited. AS patients were older showing more CV risk factors and higher values of C reactive protein and erythrocyte sedimentation rate (ESR) than those with nr-axSpA. However, no difference in the prevalence of carotid plaques or in the cIMT was found between both groups in the adjusted analysis. The percentage of patients reclassified from the low and moderate CV risk categories to the very high-risk category due to the presence of carotid plaques was comparable in AS and nr-axSpA (10.7% versus 10.1% and 40.5% versus 45.5%, respectively). A model containing age, BASFI and ESR applied to moderate risk axSpA patients identified 41% of these patients as having very high-risk patients with high specificity (88%). Conclusion: The atherosclerosis burden is similar in nr-axSpA and AS. As occurred for AS, more than 40% of axSpA patients included in the category of moderate CV risk according to the SCORE are reclassified into very high risk after carotid US, and a clinically relevant proportion of them can be detected by applying a model containing age, BASFI and ESR.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: González Mazón I., Rueda-Gotor J., Ferraz-Amaro I., Genre F., Corrales A., Calvo Rio V., Palmou Fontana N., Portilla V., Llorca J., Mata C., Hernández-Hernández V., Quevedo-Abeledo J.C., Rodríguez-Lozano C., Lopez Medina C., Ladehesa-Pineda M.L., Castañeda S., Vicente E.F., Fernández-Carballido C., Martínez-Vidal M.P., Castro-Corredor D., Anino-Fernández J., Peiteado D., Plasencia-Rodríguez C., García-Vivar M.L., Galíndez-Agirregoikoa E., Montes

 Fuente: Semin Arthritis Rheum . 2021 Apr;51(2):395-403.

Editorial: Elsevier

 Año de publicación: 2021

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.semarthrit.2021.02.003

ISSN: 0049-0172,1532-866X

Url de la publicación: https://doi.org/10.1016/j.semarthrit.2021.02.003

Autores/as

IÑIGO GONZALEZ MAZON

JAVIER RUEDA GOTOR

FERRAZ-AMARO, IVÁN

FERNANDA GENRE

ALFONSO FERNANDO CORRALES MARTINEZ

CALVO RIO, VANESA

NATALIA PALMOU FONTANA

VIRGINIA PORTILLA GONZALEZ

HERNÁNDEZ-HERNÁNDEZ, VANESA

QUEVEDO-ABELEDO, JUAN CARLOS

RODRÍGUEZ-LOZANO, CARLOS

LOPEZ MEDINA, CLEMENTINA

LADEHESA-PINEDA, MARÍA LOURDES

CASTAÑEDA, SANTOS

VICENTE, ESTHER F.

FERNÁNDEZ-CARBALLIDO, CRISTINA