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BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis

Abstract: BAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes and autoimmunity. Additionally, BAFF, APRIL and BAFFR polymorphisms were associated with immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several autoimmune diseases. Accordingly, we assessed whether BAFF, APRIL and BAFFR represent novel genetic risk factors for Immunoglobulin-A vasculitis (IgAV), a predominantly B-lymphocyte inflammatory condition. BAFF rs374039502, which colocalizes with BAFF GCTGT>A, and two tag variants within APRIL (rs11552708 and rs6608) and BAFFR (rs7290134 and rs77874543) were genotyped in 386 Caucasian IgAV patients and 806 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when BAFF, APRIL and BAFFR variants were analysed independently. Likewise, no statistically significant differences were found in the genotype and allele frequencies of BAFF, APRIL or BAFFR when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when APRIL and BAFFR haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that BAFF, APRIL and BAFFR do not contribute to the genetic network underlying IgAV.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Prieto-Peña D., Genre F., Remuzgo-Martínez S., Pulito-Cueto V., Atienza-Mateo B., Llorca J., Sevilla-Pérez B., Ortego-Centeno N., Lera-Gómez L., Leonardo M.T., Peñalba A., Narváez J., Martín-Penagos L., Rodrigo E., Miranda-Filloy J.A., Caminal-Montero L., Collado P., Pérez J.S., de Argila D., Rubio E., Luque M.L., Blanco-Madrigal J.M., Galíndez-Agirregoikoa E., Gualillo O., Martín J., Castañeda S., Blanco R., González-Gay M.A., López-Mejías

 Fuente: Sci Rep . 2021 Jun 1;11(1):11510

 Año de publicación: 2021

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s41598-021-91055-z

ISSN: 2045-2322

Url de la publicación: https://doi.org/10.1038/s41598-021-91055-z

Autores/as

DIANA PRIETO PEÑA

FERNANDA GENRE

REMUZGO MARTÍNEZ, SARA

VERONICA PULITO CUETO

BELÉN ATIENZA MATEO

SEVILLA PÉREZ, BELÉN

ORTEGO CENTENO, NORBERTO

LERA GÓMEZ, LETICIA

LEONARDO, MARÍA TERESA

PEÑALBA, ANA

NARVÁEZ, JAVIER

LUIS MARTIN PENAGOS

MIRANDA FILLOY, JOSÉ A.

CAMINAL MONTERO, LUIS

COLLADO, PAZ

RICARDO BLANCO ALONSO