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Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis

Abstract: Cytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of several immune-mediated diseases has been described. Accordingly, we assessed whether the IL33-IL1RL1 pathway represents a novel genetic risk factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) and three within IL1RL1 (rs2310173, rs13015714 and rs2058660), that also were previously associated with several inflammatory diseases, were genotyped in 380 Caucasian IgAV patients and 845 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when IL33 and IL1RL1 variants were analysed independently. Likewise, no statistically significant differences were found in IL33 or IL1RL1 genotype and allele frequencies when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when IL33 and IL1RL1 haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that the IL33-IL1RL1 signalling pathway does not contribute to the genetic network underlying IgAV.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Prieto-Peña D., Remuzgo-Martínez S., Genre F., Pulito-Cueto V., Atienza-Mateo B., Llorca J., Sevilla-Pérez B., Ortego-Centeno N., Marquez A., Lera-Gómez L., Leonardo M.T., Peñalba A., Narváez J., Martín-Penagos L., Rodrigo E., Miranda-Filloy J.A., Caminal-Montero L., Collado P., Sánchez Pérez J., de Argila D., Rubio E., León Luque M., Blanco-Madrigal J.M., Galíndez-Agirregoikoa E., Gualillo O., Martín J., Castañeda S., Blanco R., González-G

 Fuente: Sci Rep . 2021 Aug 9;11(1):16163

 Año de publicación: 2021

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s41598-021-95762-5

ISSN: 2045-2322

Url de la publicación: https://doi.org/10.1038/s41598-021-95762-5

Autores/as

DIANA PRIETO PEÑA

REMUZGO-MARTÍNEZ, SARA

GENRE, FERNANDA

VERONICA PULITO CUETO

BELÉN ATIENZA MATEO

SEVILLA-PÉREZ, BELÉN

ORTEGO-CENTENO, NORBERTO

MARQUEZ, ANA

LERA-GÓMEZ, LETICIA

LEONARDO, MARÍA TERESA

PEÑALBA, ANA

NARVÁEZ, JAVIER

LUIS MARTIN PENAGOS

MIRANDA-FILLOY, JOSÉ A

CAMINAL-MONTERO, LUIS

RICARDO BLANCO ALONSO