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Coffee consumption and colorectal cancer risk: a multicentre case-control study from Italy and Spain

Abstract: Background: Coffee contains many bioactive substances that can play a role on colorectal cancer. Epidemiological evidence of coffee intake and colorectal cancer is, however, inconsistent. Aim: To provide further information on the risk of colorectal cancer in relation to coffee consumption. Methods: Data derive from two companion case-control studies conducted in Italy and Spain within the European Union Project on Health Impacts of long-term exposure to disinfection by-products in Drinking Water and the Spanish Multi-Case Control study on Cancer. These included a total of 2289 incident cases with colorectal cancer and 3995 controls with information on coffee intake. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were derived from unconditional logistic regression models, adjusted for study centre, sex, age, education, smoking, and other covariates. Results: Compared with never coffee drinkers, the OR was 0.99 (95% CI 0.95-1.02) for total coffee consumption. There was no significant trend in risk with dose or duration, the ORs being 0.95 (95% CI 0.72-1.25) for an amount of five or more cups per day of coffee and 0.95 (95% CI 0.75-1.19) for a duration of consumption of 50 years or longer. The OR was 1.04 (95% CI 0.87-1.25) for two or more cups per day of decaffeinated coffee. There were no heterogeneity across strata of various covariates, as well as no apparent differences between various anatomical subsites. Conclusion: This large pooled analysis of two studies shows no association of coffee and decaffeinated coffee with colorectal cancer risk.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Eur J Cancer Prev . 2021 May 1;30(3):204-210.

Editorial: Lippincott, Williams & Wilkins

 Año de publicación: 2021

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1097/CEJ.0000000000000593.

ISSN: 0959-8278,1473-5709

Url de la publicación: https://doi.org/10.1097/cej.0000000000000593

Autores/as

ROSATO, VALENTINA

GUERCIO, VALENTINA

BOSETTI, CRISTINA

GRACIA-LAVEDAN, ESTHER

VILLANUEVA, CRISTINA M.

POLESEL, JERRY

TOFFOLUTI, FEDERICA

MORENO, VICTOR

MARTIN, VICENTE

ARAGONÉS, NURIA

OLMEDO-REQUENA, ROCÍO

GUEVARA, MARCELA

AMIANO, PILAR

SALAS, DOLORES

FERNANDEZ-TARDON, GUILLERMO

ALGUACIL, JUAN

CHIRLAQUE LÓPEZ, MARÍA DOLORES

FERNANDEZ-VILLA, TANIA

PÉREZ-GÓMEZ, BEATRIZ

JIMÉNEZ-MOLEÓN, JOSE J.

MORENO-IRIBAS, CONCHI

JOSÉ MOLINA, ANTONIO

CASTAÑO VINYALS, GEMMA

POLLAN, MARINA

KOGEVINAS, MANOLIS

LA VECCHIA, CARLO

TAVANI, ALESSANDRA