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Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study

Abstract: Background: Vaspin is a novel anti-inflammatory adipokine associated with cardiovascular (CV) disease and inflammation in chronic inflammatory conditions different from axial spondyloarthritis (axSpA). Given the high incidence of CV disease (mainly due to accelerated atherosclerosis) exhibited by axSpA patients, we wondered if vaspin could also be a key molecule in this process. However, data on the role of vaspin regarding atherosclerotic disease in the context of axSpA is scarce. For this reason, we aimed to evaluate the implication of vaspin, at the genetic and serological level, in subclinical atherosclerosis and CV risk in axSpA. Methods: This study included 510 patients diagnosed with axSpA. Carotid ultrasound (US) was performed to evaluate the presence of subclinical atherosclerosis. Three vaspin gene variants (rs2236242, rs7159023, and rs35262691) were genotyped by TaqMan probes. Serum vaspin levels were assessed by enzyme-linked immunosorbent assay. Statistical analysis was performed using STATA® v.11.1. Results: Serum vaspin levels were significantly higher in female patients than in males and also in obese patients when compared to those with normal weight (p < 0.05). At the genetic level, we disclosed that the minor allele of rs2236242 (A) was associated with lower serum vaspin levels in axSpA, while the rs7159023 minor allele (A) was linked to higher serum levels (p < 0.05). When the three polymorphisms assessed were combined conforming haplotypes, we disclosed that the TGC haplotype related to high serum levels of vaspin (p = 0.01). However, no statistically significant association was observed between vaspin and markers of subclinical atherosclerosis, both at the genetic and serological level. Conclusions: Our results revealed that vaspin is linked to CV risk factors that may influence on the atherosclerotic process in axSpA. Additionally, we disclosed that serum vaspin concentration is genetically modulated in a large cohort of patients with axSpA.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Arthritis Res Ther . 2021 Apr 13;23(1):111.

Editorial: BioMed Central

 Año de publicación: 2021

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1186/s13075-021-02499-7

ISSN: 1478-6354,1478-6362

Url de la publicación: https://doi.org/10.1186/s13075-021-02499-7

Autores/as

JAVIER RUEDA GOTOR

RAQUEL LOPEZ MEJIAS

VERONICA PULITO CUETO

ALFONSO FERNANDO CORRALES MARTINEZ

LERA GÓMEZ, LETICIA

VIRGINIA PORTILLA GONZALEZ

IÑIGO GONZALEZ MAZON

EXPÓSITO, ROSA

MATA, CRISTINA

FRANCISCO JAVIER LLORCA DIAZ

HERNÁNDEZ HERNÁNDEZ, VANESA

RODRÍGUEZ LOZANO, CARLOS

BARBARROJA, NURIA

ORTEGA CASTRO, RAFAELA

VICENTE, ESTHER

FERNÁNDEZ CARBALLIDO, CRISTINA

MARTÍNEZ VIDAL, MARÍA PAZ

CASTRO CORREDOR, DAVID

ANINO FERNÁNDEZ, JOAQUÍN

PEITEADO, DIANA

PLASENCIA RODRÍGUEZ, CHAMAIDA

GALÍNDEZ-AGIRREGOIKOA, EVA

GARCÍA-VIVAR, MARÍA LUZ

GUALILLO, ORESTE

QUEVEDO-ABELEDO, JUAN CARLOS

CASTAÑEDA, SANTOS

FERNANDA GENRE