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Consumption of ultra-processed food and drinks and chronic lymphocytic leukemia in the MCC-Spain study

Abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. Its etiology is largely unknown but increasing incidence rates observed worldwide suggest that lifestyle and environmental factors such as diet might play a role in the development of CLL. Hence, we hypothesized that the consumption of ultra-processed food and drinks (UPF) might be associated with CLL. Data from a Spanish population-based case-control study (MCC-Spain study) including 230 CLL cases (recruited within three years of diagnosis) and 1634 population-based controls were used. The usual diet during the previous year was collected through a validated food frequency questionnaire and food and drink consumption was categorized using the NOVA classification scheme. Logistic regression models adjusted for potential confounders were used. Overall, no association was reported between the consumption of UPF and CLL cases (OR per each 10% increase of the relative contribution of UPF to total dietary intake = 1.09 (95% CI: 0.94; 1.25)), independently of the Rai stage at diagnosis. However, when analyses were restricted to cases diagnosed within <1 year (incident), each 10% increment in the consumption of UPF was associated with a 22% higher odds ratio of CLL (95% CI: 1.02, 1.47) suggesting that the overall results might be affected by the inclusion of prevalent cases, who might have changed their dietary habits after cancer diagnosis. Given the low number of cases in the subgroup analyses and multiple tests performed, chance findings cannot totally be ruled out. Nonetheless, positive associations found in CLL incident cases merit further research, ideally in well-powered studies with a prospective design.

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 Autoría: Solans M., Fernández-Barrés S., Romaguera D., Benavente Y., Marcos-Gragera R., Gracia-Lavedan E., Costas L., Robles C., Gonzalez-Barca E., Banda E.d.l., Alonso E., Aymerich M., Campo E., Llorca J., Fernández-Tardón G., Olmedo-Requena R., Gimeno E., Castaño-Vinyals G., Aragonés N., Kogevinas M., Pollán M., Sanjose S.d., Amiano P., Casabonne D.,

 Fuente: Int J Environ Res Public Health . 2021 May 20;18(10):5457

Editorial: MDPI

 Año de publicación: 2021

Nº de páginas: 12

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/ijerph18105457

ISSN: 1661-7827,1660-4601

Proyecto español: CEX2018-000806-S

Url de la publicación: https://doi.org/10.3390/ijerph18105457

Autores/as

SOLANS, MARTA

FERNÁNDEZ-BARRÉS, SÍLVIA

ROMAGUERA, DORA

BENAVENTE, YOLANDA

MARCOS-GRAGERA, RAFAEL

GRACIA-LAVEDAN, ESTHER

COSTAS, LAURA

ROBLES, CLAUDIA

GONZALEZ-BARCA, EVA

DE LA BANDA, ESMERALDA

ALONSO, ESTHER

AYMERICH, MARTA

FERNÁNDEZ-TARDÓN, GUILLERMO

OLMEDO-REQUENA, ROCÍO

GIMENO, EVA

CASTAÑO-VINYALS, GEMMA

ARAGONÉS, NURIA

KOGEVINAS, MANOLIS