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The presence of both HLA-DRB1*04:01 and HLA-B*15:01 increases the susceptibility to cranial and extracranial giant cell arteritis

Abstract: Objectives: To determine if patients with the predominant extracranial large-vessel-vasculitis (LVV) pattern of giant cell arteritis (GCA) have a distinctive HLA-B association, different from that reported in biopsy-proven cranial GCA patients. In a further step we assessed if the combination of HLA-B and HLA-DRB1 alleles confers an increased risk for GCA susceptibility, either for the cranial and extracranial LVV phenotypes. Methods: A total of 184 patients with biopsy-proven cranial GCA, 105 with LVV-GCA and 486 healthy controls were included in our study. We compared HLA-B phenotype frequencies between the three groups. Results: HLA-B*15 phenotype was significantly increased in patients with classic cranial GCA compared to controls (14.7% versus 5.8%, respectively; p<0.01; OR [95% CI] =2.81 [1.54-5.11]). It was mainly due to the HLA-B*15:01 allele (12.5% versus 4.0%, respectively; p<0.01; OR [95% CI] =3.51 [1.77-6.99]) and remained statistically significant after Bonferroni correction. Similar HLA-B*15 association was observed in patients with the LVV-GCA (11.4% versus 5.8%, p=0.04, OR [95% CI] =2.11 [1.04-4.30]). This association was also mainly due to the HLA-B*15:01 allele (10.5% versus 4.0%, respectively; p=0.0054; OR [95% CI] =2.88 [1.19-6.59]). Noteworthy, the presence of HLA-B*15:01 together with HLA-DRB1*04:01 led to an increased risk of developing both cranial and extracranial LVV-GCA. Conclusions: Susceptibility to GCA is strongly related to the HLA region, regardless of the clinical phenotype of expression of the disease.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Prieto-Peña D., Remuzgo-Martínez S., Ocejo-Vinyals J.G., Atienza-Mateo B., Genre F., Jiménez A.M., Ortiz-Sanjuán F., Romero-Yuste S., Moriano C., Galíndez-Agirregoikoa E., Calvo I., Ortego-Centeno N., Álvarez-Rivas N., Miranda-Filloy J.A., Llorente I., García-García J., Blanco R., Gualillo O., Martín J., Castañeda S., López-Mejías R., González-Gay M.A.,

 Fuente: Clin Exp Rheumatol . Mar-Apr 2021;39 Suppl 129(2):21-26

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2021

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Autores/as

DIANA PRIETO PEÑA

REMUZGO-MARTÍNEZ, SARA

OCEJO-VINYALS, JAVIER GONZALO

BELÉN ATIENZA MATEO

GENRE, FERNANDA

MUÑOZ-JIMENEZ, ALEJANDRO

ORTIZ-SANJUÁN, FRANCISCO

ROMERO-YUSTE, SUSANA

MORIANO, CLARA

GALINDEZ-AGIRREGOIKOA, EVA

CALVO, ITZIAR

ORTEGO-CENTENO, NORBERTO

ÁLVAREZ-RIVAS, NOELIA

MIRANDA-FILLOY, JOSÉ A

LLORENTE, IRENE

GARCÍA-GARCÍA, JAVIER

RICARDO BLANCO ALONSO

GUALILLO, ORESTE

MARTIN, JAVIER

CASTAÑEDA, SANTOS

LOPEZ-MEJÍAS, RAQUEL