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Mural Endocarditis: The GAMES Registry Series and Review of the Literature

Abstract: Introduction: Mural infective endocarditis (MIE) is a rare type of endovascular infection. We present a comprehensive series of patients with mural endocarditis. Methods: Patients with infectious endocarditis (IE) from 35 Spanish hospitals were prospectively included in the GAMES registry between 2008 and 2017. MIEs were compared to non-MIEs. We also performed a literature search for cases of MIE published between 1979 and 2019 and compared them to the GAMEs series. Results: Twenty-seven MIEs out of 3676 IEs were included. When compared to valvular IE (VIE) or device-associated IE (DIE), patients with MIE were younger (median age 59 years, p \0.01). Transplantation (18.5% versus 1.6% VIE and 2% DIE, p \ 0.01), hemodialysis (18.5% versus 4.3% VIE and 4.4% DIE, p = 0.006), catheter source (59.3% versus 9.7% VIE and 8.8% DIE, p \ 0.01) and Candida etiology (22.2% versus 2% DIE and 1.2% VIE, p \ 0.01) were more common in MIE, whereas the Charlson Index was lower (4 versus 5 in non MIE, p = 0.006). Mortality was similar.MIE from the literature shared many characteristics with MIE from GAMES, although patients were younger (45 years vs. 56 years, p \ 0.001), the Charlson Index was lower (1.3 vs. 4.3, p = 0.0001), catheter source was less common (13.9% vs. 59.3%) and there were more IVDUs (25% vs. 3.7%). S. aureus was the most frequent microorganism (50%, p = 0.035). Systemic complications were more common but mortality was similar. Conclusion: MIE is a rare entity. It is often a complication of catheter use, particularly in immunocompromised and hemodialysis patients. Fungal etiology is common. Mortality is similar to other IEs.

 Fuente: Infectious Diseases and Therapy (2021) 10:2749?2764

Editorial: Springer Nature

 Fecha de publicación: 26/07/2021

Nº de páginas: 16

Tipo de publicación: Artículo de Revista

 DOI: doi.org/10.1007/s40121-021-00490-y

ISSN: 2193-8229,2193-6382

Url de la publicación: https://doi.org/10.1007/s40121-021-00490-y

Autores/as

GUTIÉRREZ VILLANUEVA, ANDREA

MUÑOZ, PATRICIA

DELGADO MONTERO, ANTONIA

OLMEDO SAMPERIO, MARIA

ALARCÓN, ARÍSTIDES DE

GUTIÉRREZ CARRETERO, ENCARNACIÓN

ZARAUZA, JESÚS

GARCÍA I PARES, DELIA

GOENAGA, MIGUEL ÁNGEL

OJEDA BURGOS, GUILLERMO

GOIKOETXEA AGIRRE, ANE JOSUNE

REGUERA IGLESIAS, JOSÉ Mª

RAMOS, ANTONIO

FERNÁNDEZ CRUZ, ANA