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Measurement of galactosyl-deficient IgA1 by the monoclonal antibody KM55 contributes to predicting patients with IgA nephropathy with high risk of long-term progression

Abstract: Backgroundandobjective:About25%ofpatientswithIgAnephropathy(IgAN)progresstostage5chronickidneydisease(CKD)afteryearsofevolution.Varioustoolshavebeendevelopedinrecentyearsdesignedtopredictwhichofthepatientswillhadpooreroutcomes.Thevalueofcirculatinggalactosyl-deficientIgA1(Gd-IgA1)hasbeenrelatedtoaworseevolutionofIgANinseveralstudies.TherearealsosomepublicationsthatrelatehigherAPRILvalueswithaworseevolution.Recently,anewmethodhasbeendevelopedthatallowsmeasuringthevalueofcirculatingGd-IgA1inasimplerwaythanthosepreviouslyavailable.TheobjectiveofthisstudyistoanalyzetheinfluenceofcirculatingGd-IgA1,measuredbythismethod,ontheprogressionofIgAN.Materialsandmethods:Forty-ninepatientswithadiagnosisofIgANdemonstratedbyrenalbiopsywereselectedinourcenter,withouthavingreceivedpriorimmunosuppressivetreat-ment,forwhomfrozenserumwasavailable.Themedianfollow-upwas4years.Gd-IgA1wasmeasuredbylectin-independentELISAwiththemonoclonalantibodyKM55(IgA1kitCat.No.30111694.IBLInt.,Hamburg,Germany).Likewise,APRILlevelswerealsomeasuredinthesepatients.Results:19(38.8%)patientsreachedstage5CKD.ThefourthquartileofcirculatingGd-IgA1wasrelatedtoahighercumulativeriskofreachingstage5CKDintheKaplan?Meieranalysis(riskatthe5thyear39.4%vs.24.3%,logrankp=0.019).TheGd-IgA1valuewasrelatedto anincreasedriskofCKDstage5(HR1.147,95%CI1.035?1.270,p=0.009),regardlessofglomerularfiltrationrate,proteinuria,thepercentageofsclerosedglomeruliandthevalueofsegmentalsclerosis.WedidnotfindsignificantdifferencesintheAPRILvalues.Conclusions:ThevalueofcirculatingGd-IgA1measuredbythemonoclonalantibodyKM55isrelatedtoaworseevolutionofpatientswithIgANindependentlyofothervariables,soitcouldbeincludedinthestudyofpatientstoimprovethepredictionoftheriskofdiseaseprogression.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Nefrología Vol. 41. Issue. 3.May - June 2021 pages 227-366

Editorial: Elsevier

 Año de publicación: 2021

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: doi.org/10.1016/j.nefroe.2021.06.004

ISSN: 0211-6995,1989-2284

Url de la publicación: https://doi.org/10.1016/j.nefroe.2021.06.004

Autores/as

LUIS MARTIN PENAGOS

BENITO-HERNÁNDEZ, ADALBERTO

MAZÓN, JAIME

MARINA DE COS GOMEZ

VICTORIA OVIEDO, MARÍA

DAVID SAN SEGUNDO ARRIBAS

JUAN CARLOS RUIZ SAN MILLAN