Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Impact of donor-recipient age on cardiac transplant survival. Subanalysis of the Spanish Heart Transplant Registry

Abstract: Introduction and objectives: The age of heart transplant recipients and donors is progressively increasing. It is likely that not all donor-recipient age combinations have the same impact on mortality. The objective of this work was to compare survival in transplant recipients according to donor-recipient age combinations. Methods: We performed a retrospective analysis of transplants performed between 1 January 1993 and 31 December 2017 in the Spanish Heart Transplant Registry. Pediatric transplants, retransplants and combined transplants were excluded (6505 transplants included). Four groups were considered: a) donor < 50 years for recipient < 65 years; b) donor < 50 years for recipient 65 years; c) donor 50 years for recipient 65 years, and d) donor 50 years for recipient < 65 years. Results: The most frequent group was young donor for young recipient (73%). There were differences in the median survival between the groups (P < .001): a) younger-younger: 12.1 years, 95%CI, 11.5-12.6; b) younger-older: 9.1 years, 95%CI, 8.0-10.5; c) older-older: 7.5 years, 95%CI, 2.8-11.0; d) older-younger: 10.5 years, 95%CI, 9.6-12.1. On multivariate analysis, independent predictors of mortality were the age of the donor and the recipient (0.008 and 0.001, respectively). The worst combinations were older-older vs younger-younger (HR, 1.57; 95%CI, 1.22-2.01; P < .001) and younger-older vs younger-younger (HR, 1.33; 95%CI, 1.12-1.58; P = .001). Conclusions: Age (of the donor and recipient) is a relevant prognostic factor in heart transplant. The donor-recipient age combination has prognostic implications that should be identified when accepting an organ for transplant.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Revista Española de Cardiología Volume 74, Issue 5, May 2021, Pages 393-401

Editorial: Doyma

 Fecha de publicación: 01/05/2021

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: doi.org/10.1016/j.rec.2020.02.016

ISSN: 0300-8932,1579-2242

Url de la publicación: https://doi.org/10.1016/j.rec.2020.02.016

Autores/as

LÓPEZ-VILELLA, RAQUEL

CRESPO-LEIRO, MARÍA G.

SEGOVIA-CUBERO, JAVIER

MANUEL COBO BELAUSTEGUI

DELGADO-JIMÉNEZ, JUAN

ARIZÓN DEL PRADO, JOSÉ MARÍA

MARTÍNEZ-SELLÉS, MANUEL

SOBRINO MÁRQUEZ, JOSÉ MANUEL

MIRABET-PÉREZ, SONIA

GONZÁLEZ-COSTELLO, JOSÉ

PÉREZ-VILLA, FÉLIX

LAMBERT-RODRÍGUEZ, JOSÉ LUIS

RÁBAGO-ARACIL, GREGORIO

BLASCO-PEIRÓ, MARÍA TERESA

FUENTE-GALÁN, LUIS DE LA

GARRIDO-BRAVO, IRIS

OTERO, DÉBORAH

ALMENAR-BONET, LUIS