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B-cell lymphoma mutations: improving diagnostics and enabling targeted therapies

Abstract: B-cell lymphomas comprise an increasing number of clinicopathological entities whose characterization has historically been based mainly on histopathological features. In recent decades, the analysis of chromosomal aberrations as well as gene and miRNA expression profile studies have helped distinguish particular tumor types and also enabled the detection of a number of targets with therapeutic implications, such as those activated downstream of the B-cell receptor. Our ability to identify the mechanisms involved in B-cell lymphoma pathogenesis has been boosted recently through the use of Next Generation Sequencing techniques in the analysis of human cancer. This work summarizes the recent findings in the molecular pathogenesis of B-cell neoplasms with special focus on those clinically relevant somatic mutations with the potential to be explored as candidates for the development of new targeted therapies. Our work includes a comparison between the mutational indexes and ranges observed in B-cell lymphomas and also with other solid tumors and describes the most striking mutational data for the major B-cell neoplasms. This review describes a highly dynamic field that currently offers many opportunities for personalized therapy, although there is still much to be gained from the further molecular characterization of these clinicopathological entities.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Haematologica. 2014 Feb; 99(2): 222–231

Editorial: Pavia, Italy : Ferrata Storti Foundation

 Fecha de publicación: 01/02/2014

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.3324/haematol.2013.096248

ISSN: 0390-6078,1592-8721

Proyecto español: SAF2008-03871

Autores/as

MARTINEZ MAGUNACELAYA, NEREA

MARIA ANA BATLLE LOPEZ

CRISTINA PEREZ MENENDEZ

SANTIAGO MONTES MORENO

SÁNCHEZ BEATO, MARGARITA

MIGUEL ANGEL PIRIS PINILLA