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Active psychosis and pro-inflammatory cytokines in first-episode of psychosis

Abstract: Higher levels of pro-inflammatory cytokines are consistently found in the serum of first episode psychosis (FEP) patients and this immune dysfunction could contribute to neural harm. On the other hand, lengthy periods of active psychosis during the early phases of the illness appear to be associated to worst functional outcome. We aim to explore the possible relationship between lengthy periods of active psychosis during early phases of the illness and the levels of pro-inflammatory cytokines. This is a prospective clinical study consisting of a 3-year clinical follow-up. We assessed the relation between the duration of active psychosis in patients with FEP and the serum levels of 21 cytokines at baseline and 3 months after initiating antipsychotic medication. We used the Human High Sensitivity T Cell Magnetic Bead Panel protocol from the Milliplex® Map Kit. The sample consisted of 59 patients with a FEP. The percentage of variation of the serum levels of the chemokine MIP-3? during the first 3 months of antipsychotic treatment and the score in negative psychotic symptoms 3 months after the initiation of antipsychotic medication, acted as predictors of the initial time to remission of positive psychotic symptoms. Our findings open the possibility to investigating the potential use of the variation in chemokine MIP3? serum levels during the first months of antipsychotic treatment to identify a subtype of FEP patients that could benefit from an add-on treatment with immune modulators.

 Fuente: Journal of Psychiatric Research Volume 134, February 2021, Pages 150-157

Editorial: Elsevier

 Fecha de publicación: 01/02/2021

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.jpsychires.2020.12.060

ISSN: 0022-3956,1879-1379

Url de la publicación: https://doi.org/10.1016/j.jpsychires.2020.12.060

Autores/as

PARDO-DE-SANTAYANA, GUILLERMO

MARÍA JUNCAL RUIZ

RIESCO-DÁVILA, LAURA

VICTOR ORTIZ GARCIA DE LA FOZ

PELAYO-TERÁN, JOSÉ MARÍA

CRESPO-FACORRO, BENEDICTO