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Urinary C-X-C Motif Chemokine 10 Is Related to Acute Graft Lesions Secondary to T Cell- and Antibody-Mediated Damage

Abstract: Background: Non-invasive biomarkers of graft rejection are needed to optimize the management and outcomes of kidney transplant recipients. Urinary excretion of IFN-g-related chemokine CXCL10 is clearly associated with clinical and subclinical T cell-mediated graft inflammation, but its relationship with antibody-mediated damage has not been fully addressed. Further, the variables influencing levels of urinary CXCL10 excretion are unknown. Material/Methods: A total of 151 kidney graft biopsies (92 surveillance and 59 indication biopsies) and 151 matched urine samples obtained before biopsy were prospectively analyzed. T cell-mediated rejection (TCMR) and antibody-mediated rejection (AbMR) were defined according to the 2017 Banff classification criteria. Urinary CXCL10 levels were measured by ELISA and corrected by urinary creatinine. Results: Banff scores ?t?, ?i?, ?g?, and ?ptc? were significantly related to urinary CXCL10 levels. Multivariate analysis showed that ?t? (b=0.107, P=0.001) and ?ptc? (b=0.093, P=0.002) were significantly associated with urinary CXCL10. Donor specific antibodies (DSAs) were related to the high excretion of urinary CXCL10 at 1 year after transplantation (odds ratio [OR] 17.817, P=0.003). Urinary CXCL10 showed good discrimination ability for AbMR (AUC-ROC 0.760, P=0.001). The third tertile of urinary CXCL10 remained significantly associated with AbMR (OR 4.577, 95% confidence interval 1.799?11.646, P=0.001) after multivariate regression analysis. Conclusions: DSA was the only variable clearly related to high urinary CXCL10 levels. Urinary CXCL10 is a good non-invasive candidate biomarker of AbMR and TCMR, supplying information independent of renal function and other variables normally used to monitor kidney transplants

 Fuente: Annals of Transplantation 2021; 26: e929491

Editorial: International Scientific Information, Inc.

 Fecha de publicación: 09/03/2021

Nº de páginas: 12

Tipo de publicación: Artículo de Revista

 DOI: 10.12659/AOT.929491

ISSN: 1425-9524,2329-0358

Url de la publicación: https://doi.org/10.12659/AOT.929491

Autores/as

ARNAU, ALVARO

BENITO-HERNÁNDEZ, ADALBERTO

ANGELES RAMOS BARRON

MARIA TERESA GARCIA UNZUETA

GÓMEZ-ORTEGA, JOSÉ MARÍA

DAVID SAN SEGUNDO ARRIBAS

JUAN CARLOS RUIZ SAN MILLAN