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Immune Assessment of BNT162b2 m-RNA-Spike Based Vaccine Response in Adults

Abstract: Vaccine efficacy is based on clinical data. Currently, the assessment of immune response after SARS-CoV-2 vaccination is scarce. A total of 52 healthcare workers were immunized with the same lot of BNT162b2 vaccine. The immunological response against the vaccine was tested using a T-specific assay based on the expression of CD25 and CD134 after stimulation with anti-N, -S, and -M specific peptides of SARS-CoV-2. Moreover, IgG anti-S2 and -RBD antibodies were detected using ELISA. Furthermore, the cell subsets involved in the response to the vaccine were measured in peripheral blood by flow cytometry. Humoral-specific responses against the vaccine were detected in 94% and 100% after the first and second doses, respectively. Therefore, anti-S T-specific responses were observed in 57% and 90% of the subjects after the first and second doses of the vaccine, respectively. Thirty days after the second dose, significant increases in T helper 1 memory cells (p < 0.001), peripheral memory T follicular helper (pTFH) cells (p < 0.032), and switched memory (p = 0.005) were observed. This study describes the specific humoral and cellular immune responses after vaccination with the new mRNA-based BNT162b2 vaccine. A mobilization of TFH into the circulation occurs, reflecting a specific activation of the immune system.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Biomedicines . 2021 Jul 22;9(8):868

Editorial: MDPI AG

 Año de publicación: 2021

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/biomedicines9080868

ISSN: 2227-9059

Url de la publicación: https://doi.org/10.3390/ biomedicines9080868

Autoría

SAN SEGUNDO, DAVID

COMINS-BOO, ALEJANDRA

IRURE-VENTURA, JUAN

RENUNCIO-GARCÍA, MÓNICA

ROA-BAUTISTA, ADRIEL

GONZÁLEZ-LÓPEZ, ELENA

MERINO-FERNÁNDEZ, DAVID

LAMADRID-PEROJO, PATRICIA

ALONSO-PEÑA, MARTA

OCEJO-VINYALS, JAVIER GONZALO

GUTIÉRREZ-LARRAÑAGA, MARIA

GUIRAL-FOZ, SANDRA