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Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients

Abstract: Objectives: To identify disease-related factors associated with subclinical atherosclerosis and cardiovascular (CV) events in a large series of patients with axial spondyloarthritis (axSpA) and to identify possible differences in the effect of the potential pro-atherogenic factors between ankylosing spondylitis (AS) non-radiographic axSpA (nr-axSpA). Methods: This is a cross-sectional observational study of the AtheSpAin cohort, a Spanish multicenter cohort to study atherosclerosis in axSpA. Subclinical atherosclerosis determined by carotid ultrasound included assessment of carotid intima-media thickness (cIMT) and plaque detection. Results: 639 AS and 167 nr-axSpA patients were recruited. CV risk factors (CRF) and several disease-related factors showed a statistically significant association with subclinical atherosclerosis in the crude analysis. After adjustment for age, sex, and smoking (model 1), associations remained statistically significant for spinal mobility, inflammatory bowel disease, use of prednisone, and Disease-modifying antirheumatic drugs (DMARD) when assessing carotid plaques and for acute phase reactants (APR) at diagnosis, use of prednisone, DMARD, and TNF-inhibitors when measuring cIMT. In model 2, which also included classic CRF as confounding factors to identify axSpA features with a potential independent pro-atherogenic effect, the functional status was the only variable significantly associated with plaques and the use of prednisone and APR at diagnosis with cIMT. No association differences were found between both subtypes of patients. Besides, APR at diagnosis were also associated with subsequent development of CV events that had occurred in 33 patients. Conclusion: Apart from CRF, atherosclerotic disease in AxSpA is associated with disease-related factors such as inflammatory response and disease severity, with no differences between AS and nr-axSpA.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Semin Arthritis Rheum . 2022 May 28;55:152037

Editorial: Elsevier

 Año de publicación: 2022

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.semarthrit.2022.152037

ISSN: 0049-0172,1532-866X

Url de la publicación: https://doi.org/10.1016/j.semarthrit.2022.152037

Autores/as

JAVIER RUEDA GOTOR

FERRAZ AMARO, IVÁN

GENRE, FERNANDA

GONZÁLEZ MAZÓN, ÍÑIGO

CORRALES, ALFONSO

CALVO RÍO, VANESA

PORTILLA, VIRGINIA

EXPÓSITO, ROSA

HERNÁNDEZ HERNÁNDEZ, VANESA

QUEVEDO ABELEDO, JUAN CARLOS

RODRÍGUEZ LOZANO, CARLOS

LÓPEZ MEDINA, CLEMENTINA

LADEHESA-PINEDA, MARÍA LOURDES

CASTAÑEDA, SANTOS

VICENTE, ESTHER F.

FERNÁNDEZ-CARBALLIDO, CRISTINA

MARTÍNEZ-VIDAL, M PAZ