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 Detalle_Publicacion

Increased risk of MAFLD and Liver Fibrosis in Inflammatory Bowel Disease Independent of Classic Metabolic Risk Factors

Abstract: ackground & Aims There is conflicting evidence regarding the prevalence of and risk factors for metabolic-associated fatty liver disease (MAFLD) in patients with inflammatory bowel disease (IBD). We aimed to determine MAFLD prevalence and risk factors in IBD patients. Methods Cross-sectional, case-control study included all consecutive IBD patients treated at 2 different university hospitals. Controls were subjects randomly selected from the general population and matched by age, sex, type 2 diabetes status, and body mass index in a 1:2 ratio. MAFLD was confirmed by controlled attenuation parameter. Liver biopsies were collected when MAFLD with significant liver fibrosis was suspected. In addition, age- and fibrosis stage?paired non-IBD patients with biopsy-proven MAFLD served as a secondary control group. Results Eight hundred thirty-one IBD patients and 1718 controls were included. The prevalence of MAFLD and advanced liver fibrosis (transient elastography ?9.7 kPa) was 42.00% and 9.50%, respectively, in IBD patients and 32.77% and 2.31%, respectively, in the general population (P < .001). A diagnosis of IBD was an independent predictor of MAFLD (adjusted odds ratio, 1.99; P < .001) and an independent risk factor for advanced liver fibrosis (adjusted odds ratio, 5.55; P < .001). Liver biopsies were obtained from 40 IBD patients; MAFLD was confirmed in all cases, and fibrosis of any degree was confirmed in 25 of 40 cases (62.5%). Body mass index and type 2 diabetes prevalence were significantly lower in IBD-MAFLD patients than in severity-paired patients with biopsy-proven MAFLD. Conclusions MAFLD and liver fibrosis are particularly prevalent in IBD patients, regardless of the influence of classic metabolic risk factors.

 Fuente: Clinical Gastroenterology and Hepatology 3 February 2022

Editorial: Elsevier

 Fecha de publicación: 01/02/2022

Nº de páginas: 16

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.cgh.2022.01.039

ISSN: 1542-3565,1542-7714

Proyecto español: PI18/01304

Url de la publicación: https://doi.org/10.1016/j.cgh.2022.01.039

Autores/as

RODRÍGUEZ-DUQUE, JUAN CARLOS

CALLEJA, JOSÉ LUIS

PAULA IRUZUBIETA COZ

HERNÁNDEZ-CONDE, MARTA

RIVAS-RIVAS, CORAL

VERA, MARÍA ISABEL

GARCÍA, MARÍA JOSÉ

PASCUAL, MARTA

CASTRO, BEATRIZ

AGUSTIN GARCIA BLANCO

GARCÍA-NIETO, ENRIQUE

SORAYA CURIEL DEL OLMO

MARIA LUISA CAGIGAL COBO

LÓPEZ-MONTEJO, LORENA

FERNÁNDEZ-LAMAS, TATIANA

RASINES, LAURA

JOSE IGNACIO FORTEA ORMAECHEA

FRÍAS, YZA

MONTSERRAT RIVERO TIRADO