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Abstract: Aim: To evaluate the usefulness of 11C-methionine PET/CT (MET) in the localization of the parathyroid
adenomas and to compare the results with those obtained with the conventional technique in doublephase
99mTc-sestamibi scintigraphy (MIBI). We evaluated the optimal timing to acquire MET images.
Material and methods: A prospective study that included 14 patients (mean age: 65.5
9.7 years) with
primary hyperparathyroidism (PH) who underwent surgery was performed. Mean serum iPTH was
108 pg/mL and serum calcium 10.8
0.9 mg/dL. MIBI (planar and SPECT) was obtained 10 min
and 2–3 h after injection of 740 MBq (20 mCi) of 99mTc-sestamibi. MET was obtained 10 min and 40 min
after injection of 740 MBq (20 mCi) of 11C-methionine. MIBI and MET images were visually evaluated and
compared. A score for 10 min and 40 min MET images from 0 (no abnormal uptake) to 3 (intense uptake)
Results: MIBI and MET were positive and concordant in 11/14 patients and in 10 of them the parathyroid
adenoma was correctly localized. In 3/14 MIBI was positive and MET negative (MIBI correctly localized
the parathyroid adenoma in 2 of them). According to the timing of MET imaging acquisition, the 10 min
and 40 min acquisition showed the same score in 10 patients, it was higher at 10 min acquisition in 3
and in 1 the parathyroid adenoma was only detected at 40 min acquisition.
Conclusion: MIBI remains the technique of choice for the localization of parathyroid adenomas in patients
with PH. MET may play a complementary role in selected patients. Delayed acquisition should be included
in the MET protocol when the early acquisition is negative.
Fuente: Rev Esp Med Nucl Imagen Mol. 2014;33(2):93–98
Año de publicación: 2014
Nº de páginas: 6
Tipo de publicación: Artículo de Revista
MARTÍNEZ RODRÍGUEZ, I
MARTÍNEZ AMADOR, N
ARCOCHA TORRES, M. DE
REMEDIOS QUIRCE PISANO
ORTEGA NAVA, F
IBAÑEZ BRAVO, S
LAVADO PÉREZ, C
BRAVO FERRER, Z
JOSE MANUEL CARRIL CARRIL