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 Detalle_Publicacion

Multivalvular Endocarditis: A Rare Condition with Poor Prognosis

Abstract: Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE). Methods. We used a retrospective analysis of the Spanish IE Registry (2008?2020). Results. From 4064 definite cases of valvular IE, 577 (14.2%) had MIE. In patients with MIE, the most common locations were mitral (552, 95.7%) and aortic (550, 95.3%), with mitral-aortic involvement present in 507 patients (87.9%). The most common etiologies were S. viridans (192, 33.3%) and S. aureus (113, 19.6%). MIE involved only native valves in 450 patients (78.0%). Compared with patients with SIE, patients with MIE had a similar age (69 vs. 67 years, respectively, p = 0.27) and similar baseline characteristics, but were more frequently men (67.1% vs. 72.9%, p = 0.005) and had a higher incidence of intracardiac complications (36.2% vs. 50.4%, p < 0.001), heart failure (42.7% vs. 52.9%, p < 0.001), surgical indication (67.7 vs. 85.1%, p < 0.001), surgery (46.3% vs. 56.3%), and in-hospital mortality (26.9% vs. 34.3%, p < 0.001). MIE was an independent predictor of in-hospital mortality (odds ratio (OR) 1.3, 95% confidence interval (CI) 1.1?1.7, p = 0.004) but did not have an independent association with 1-year mortality (OR 1.1, 95% CI 0.9?1.4, p = 0.43). Conclusions. About one-seventh of the valvular IE patients had MIE, mainly due to mitral-aortic involvement. MIE is associated with a poor in-hospital prognosis. An early diagnosis and treatment of IE might avoid its spread to a second valve. View Full-Text

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Journal of clinical medicine 2022, 11, 4736

Editorial: MDPI

 Fecha de publicación: 31/08/2022

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/jcm11164736

ISSN: 2077-0383

Url de la publicación: https://doi.org/10.3390/jcm11164736

Autores/as

ÁLVAREZ-CEBALLOS, SARA

GONZÁLEZ-RAMALLO, VÍCTOR

QUINTANA, EDUARD

MUÑOZ, PATRICIA

VILLA-MARTÍNEZ, SOFÍA DE LA

FRANCISCO ARNAIZ DE LAS REVILLAS ALMAJANO

ALARCÓN, ARÍSTIDES DE

RODRÍGUEZ-ESTEBAN, M. ÁNGELES

MIRÓ, JOSÉ M.

GOENAGA, MIGUEL ÁNGEL

GOIKOETXEA-AGIRRE. JOSUNE

GARCÍA-VÁZQUEZ, ELISA

BOIX-PALOP, LUCÍA

MARTÍNEZ-SELLÉS, MANUEL

ON BEHALF OF GAMES