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 Detalle_Publicacion

Magnetically propelled chained nanocomposites for biologically relevant media exploration

Abstract: Elongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical information in the media of interest, taking into account biophysical or biomedical purposes. In this study, we detail the magnetic actuation of magnetically propelled chained nanocomposites considering their dynamics, in which their velocity can be modulated in terms of the viscosity of the medium considered, given a magnetic field gradient. Simpler cases of distilled water, a water/glycerol mixture and a fluid made of cell extracts (imitating the cytosol of cells) of known viscosity are the basis experiments for the study of more complex media inside HeLa cells, murine NIH-3T3 fibroblasts and zebrafish larvae, offering the mechanical information required. The experimental results indicate that the magnetically propelled performance of the chained nanostructures can be precisely controlled in potentially changing scenarios, where drug and heat delivery, magnetic separation, or microfluidic technologies are demanded, using a magnetic field gradient and providing good estimations of the dynamical parameters involved.

 Fuente: J Colloid Interface Sci . Volume 629, Part A, January 2023, Pages 287-296

Editorial: Elsevier

 Año de publicación: 2023

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.jcis.2022.08.154

ISSN: 0021-9797,1095-7103

Proyecto español: MINECO-17-MAT2016-81955-REDT

Url de la publicación: https://www.doi.org/10.1016/j.jcis.2022.08.154

Autores/as

RAMOS-DOCAMPO, MIGUEL A

HURTADO, PABLO

DÁVILA-IBÁÑEZ, ANA B

PIÑEIRO, ROBERTO

SALGUEIRIÑO, VERÓNICA