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Abstract: Background: The aim of this study was to evaluate the impact of certain single-nucleotide polymorphisms (SNPs) in cabazitaxel activity and toxicity in patients with metastatic castration-resistant prostate cancer (mCRPC). Patients & methods: 56 SNPs in five genes (CYP3A4, CYP3A5, ABCB1, TUBB1 and CYP2C8) were genotyped in 67 mCRPC patients and their correlation with outcomes analyzed. Results:TUBB1-rs151352 (hazard ratio: 0.52) and CYP2C8-rs1341164 (hazard ratio: 0.53) were associated with better overall survival, and CYP2C8-rs1058932 with biochemical progression (odds ratio: 6.60) in multivariate analysis. ABCB1-rs17327624 correlated with severe toxicity ?grade 3 (odds ratio: 8.56) and CYP2C8-rs11572093 with asthenia (odds ratio: 8.12). Conclusion: Genetic variants in mCRPC patients could explain different outcomes with cabazitaxel. Nonetheless, the small sample size and the high number of SNPs analyzed mean that the results are only hypothesis-generating and require further validation.
Fuente: Pharmacogenomics . 2022 Jul;23(11):627-638
Editorial: Future Medicine Ltd
Año de publicación: 2022
Nº de páginas: 12
Tipo de publicación: Artículo de Revista
DOI: 10.2217/pgs-2022-0023
ISSN: 1462-2416,1744-8042
Url de la publicación: https://www.doi.org/10.2217/pgs-2022-0023
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RIVERA, DANIEL HERRERO
VACAS, CARMEN GARRIGÓS
KOVANDZIC, LAURA MARCOS
VÁZQUEZ, JAVIER PUENTE
ALONSO, LUCÍA A
GONZÁLEZ, BEGOÑA MELLADO
ARAGÓN, VERÓNICA CALDERERO
GRANDE, ENRIQUE
CARO, RAQUEL LUQUE
VIRIZUELA ECHABURU, JUAN A
RODRÍGUEZ MORENO, JUAN F
AINARA AZUETA ETXEBARRIA
RODRÍGUEZ-ANTONA, CRISTINA
DURÁN, IGNACIO
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