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Non-HLA Antibodies and Their Role in Highly Sensitized Patients

Abstract: Background The role of non-HLA antibody is gaining special attention in solid-organ transplantation and in highly sensitized (HS) patients because of its potential involvement in graft loss (GL) and/or antibody-mediated rejection (ABMR). The identification of non-HLA antibodies while listed may provide deeper information about the increased immunologic risk prior to transplant. We aimed to identify non-HLA antibodies pretransplant that could involve GL in HS patients. Methods Nineteen pretransplant samples from HS patients who underwent transplant at the Marqués de Valdecilla University Hospital were studied for both HLA antibodies and a panel of 39 non-HLA antigens analyzed based on Luminex platform. Results Eleven patient (57.9%) maintained the graft (KT group), whereas 8 (42.1%) had a GL within a median of 30 days. The median fluorescent intensity (MFI) of the 39 non-HLA antigens were compared within the groups, obtaining a statistically significant differences in protein tyrosine phosphatase receptor type N (P < .04) with a MFI mean of 1408 vs 4931 for KT and GL groups, respectively. However, no significant differences were observed in non-HLA MFI between ABMR and non-ABMR KT recipients. Conclusions The presence of non-HLA antibodies in HS is high. The levels of anti-protein tyrosine phosphatase receptor type N before transplant could indicate a potential risk of GL, although longitudinal studies with large number of cases are needed to define anti-non-HLA profiles of risk of ABMR.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Transplantation Proceedings, 2022, 54(9), 2439-2442

Editorial: Elsevier

 Año de publicación: 2022

Nº de páginas: 4

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.transproceed.2022.10.011

ISSN: 0041-1345,1873-2623

Url de la publicación: https://doi.org/10.1016/j.transproceed.2022.10.011

Autores/as

ROA-BAUTISTA, ADRIEL

LÓPEZ-DEL-MORAL, COVADONGA

ELENA GONZALEZ LOPEZ

MARIA GUTIERREZ LARRAÑAGA

RENUNCIO-GARCÍA, MÓNICA

CAROLINA CASTRO HERNANDEZ

MIKHALKOVICH-MIKHALKOVICH, DZMITRY

COMINS-BOO, ALEJANDRA

JUAN IRURE VENTURA

DAVID SAN SEGUNDO ARRIBAS