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Evolving Indications for Heart-Lung Transplant in Spain

Abstract: Background The outcomes of heart-lung transplant (HLT) are worse than those of heart transplant (HT) and lung transplant alone; this and the availability of mechanical assistance have meant that the indications for HLT have been changing. This study aims to analyze the evolution of indications for HLT in a country of 47 million inhabitants. Methods We performed a retrospective observational study of all HLTs performed in Spain (performed in 2 centers) from 1990 to 2020. The total number of patients included was 1751 (HT 1673 and HLT 78). After clinical adjustment, overall survival was compared between the 2 groups. Seven etiological subgroups were considered within the HLT group: (1) cardiomyopathy with pulmonary hypertension (CM + PH);, (2) Eisenmenger syndrome, (3) congenital heart disease without Eisenmenger syndrome, (4) idiopathic pulmonary arterial hypertension (IPAH), (5) cystic fibrosis, (6) chronic obstructive pulmonary disease (COPD) and/or emphysema), and (7) diffuse interstitial lung disease. Results There were a large number of differences between patients with HLT vs HT. HLT had a 2.69-fold increased probability of death in the first year compared with HT. The indications for HLT have changed over the years. In the recent period the indications are mainly congenital heart disease and Eisenmenger syndrome, with some cases of CM + PH. Other indications for HLT have virtually disappeared, mainly lung diseases (IPAH, COPD, cystic fibrosis). Median survival was low in CM + PH (18 days), diffuse interstitial lung disease (29 days), and ischemic heart disease (114 days); intermediate in Eisenmenger syndrome (600 days); and longer in IPAH, COPD and/or emphysema, and cystic fibrosis. Conclusions HLT is a procedure with high mortality. This and mechanical assists mean that the indications have changed over the years. Etiological analysis is of utmost interest to take advantage of organs and improve survival.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Transplantation Proceedings , 2022, 54(9), 2500-2502

Editorial: Elsevier

 Año de publicación: 2022

Nº de páginas: 3

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.transproceed.2022.10.003

ISSN: 0041-1345,1873-2623

Url de la publicación: https://doi.org/10.1016/j.transproceed.2022.10.003

Autores/as

LÓPEZ-VILELLA, RAQUEL

GÓMEZ BUENO, MANUEL

SOLÉ JOVER, AMPARO

LAPORTA HERNÁNDEZ, ROSALÍA

VICENTE GILLÉN, ROSARIO

GONZÁLEZ ROMÁN, ANA ISABEL

SÁNCHEZ-LÁZARO, IGNACIO

HERNÁNDEZ PÉREZ, FRANCISCO

SALES BADÍA, GABRIEL

MAR CÓRDOBA PELÁEZ, MARÍA DEL

TORREGROSA PUERTA, SALVADOR

FORTEA GIL, ALBERTO

DONOSO TRENADO, VÍCTOR

MARTÍNEZ DOLZ, LUIS

SEGOVIA CUBERO, JAVIER

ALMENAR BONET, LUIS