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Central nervous system involvement in systemic lupus erythematosus: Data from the Spanish Society of Rheumatology Lupus Register (RELESSER)

Abstract: Objectives To analyze the prevalence, incidence, survival and contribution on mortality of major central nervous system (CNS) involvement in systemic lupus erythematosus (SLE). Methods Patients fulfilling the SLE 1997 ACR classification criteria from the multicentre, retrospective RELESSER-TRANS (Spanish Society of Rheumatology Lupus Register) were included. Prevalence, incidence and survival rates of major CNS neuropsychiatric (NP)-SLE as a group and the individual NP manifestations cerebrovascular disease (CVD), seizure, psychosis, organic brain syndrome and transverse myelitis were calculated. Furthermore, the contribution of these manifestations on mortality was analysed in Cox regression models adjusted for confounders. Results A total of 3591 SLE patients were included. Of them, 412 (11.5%) developed a total of 522 major CNS NP-SLE manifestations. 61 patients (12%) with major CNS NP-SLE died. The annual mortality rate for patients with and without ever major CNS NP-SLE was 10.8% vs 3.8%, respectively. Individually, CVD (14%) and organic brain syndrome (15.5%) showed the highest mortality rates. The 10% mortality rate for patients with and without ever major CNS NP-SLE was reached after 12.3?vs 22.8 years, respectively. CVD (9.8 years) and organic brain syndrome (7.1 years) reached the 10% mortality rate earlier than other major CNS NP-SLE manifestations. Major CNS NP-SLE (HR 1.85, 1.29?2.67) and more specifically CVD (HR 2.17, 1.41?3.33) and organic brain syndrome (HR 2.11, 1.19?3.74) accounted as independent prognostic factors for poor survival. Conclusion The presentation of major CNS NP-SLE during the disease course contributes to a higher mortality, which may differ depending on the individual NP manifestation. CVD and organic brain syndrome are associated with the highest mortality rates.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Seminars in Arthritis and Rheumatism, 2023, 58, 152121

Editorial: Elsevier

 Año de publicación: 2023

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.semarthrit.2022.152121

ISSN: 0049-0172,1532-866X

Url de la publicación: https://doi.org/10.1016/j.semarthrit.2022.152121

Autores/as

MAGRO-CHECA, CESAR

RAMIRO, SOFIA

RÚA-FIGUEROA, IÑIGO

JIMENEZ, NORMAN

CAMPO-PÉREZ, VÍCTOR DEL

MARTINEZ-BARRIO, JULIA

GALINDO-IZQUIERDO, MARÍA

CALVO-ALÉN, JAIME

URIARTE-ISACELAYA, ESTHER

TOMERO-MURIEL, EVA

FREIRE-GONZÁLEZ, MERCEDES

SALGADO, EVA

VELA, PALOMA

MENA-VÁZQUEZ, NATALIA

OLIVÉ, ALEJANDRO

NARVÁEZ, JAVIER

MENOR-ALMAGRO, RAÚL

SANTOS-SOLER, GREGORIO

HERNÁNDEZ-BERIAÍN, JOSÉ A