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Novel genes and sex differences in COVID-19 severity

Abstract: Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10-22 and P = 8.1 × 10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10-8) and ARHGAP33 (P = 1.3 × 10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ?60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Hum Mol Genet . 2022 Nov 10;31(22):3789-3806

Editorial: Oxford University Press

 Año de publicación: 2022

Nº de páginas: 18

Tipo de publicación: Artículo de Revista

 DOI: 10.1093/hmg/ddac132

ISSN: 0964-6906,1460-2083

Url de la publicación: https://www.doi.org/10.1093/hmg/ddac132

Autores/as

CRUZ, RAQUEL

DIZ-DE ALMEIDA, SILVIA

LÓPEZ DE HEREDIA, MIGUEL

QUINTELA, INÉS

CEBALLOS, FRANCISCO C

PITA, GUILLERMO

LORENZO-SALAZAR, JOSÉ M

GONZÁLEZ-MONTELONGO, RAFAELA

GAGO-DOMÍNGUEZ, MANUELA

SEVILLA PORRAS, MARTA

TENORIO CASTAÑO, JAIR ANTONIO

NEVADO, JULIAN

AGUADO, JOSE MARÍA

AGUILAR, CARLOS

AGUILERA-ALBESA, SERGIO

ALMADANA, VIRGINIA

ALMOGUERA, BERTA

ALVAREZ, NURIA