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Interleukin 1 beta (IL1ß) rs16944 genetic variant as a genetic marker of severe renal manifestations and renal sequelae in Henoch-Schönlein purpura

Abstract: OBJECTIVES: Data from a small series suggested that the Interleukin 1 beta (IL1ß) rs16944 polymorphism may be associated with severe renal involvement and persistent renal damage (renal sequelae) in Henoch-Schönlein purpura (HSP). To confirm this association, we assessed the largest cohort of Caucasian HSP patients ever considered for genetic studies. METHODS: 338 Spanish HSP patients and 635 sex and ethnically matched controls were recruited in this study. All patients were required to have had at least 6 months' follow-up. Patients and controls were genotyped for IL1ß rs16944 by TaqMan genotyping assay. RESULTS: No differences between IL1ß rs16944 genotype or allele frequencies were found either in the case/control study or when HSP patients were stratified according to the age at disease onset, presence of nephritis or gastrointestinal manifestations. Nevertheless, 4 (25%) of the 16 HSP patients who developed severe renal manifestations carried the TT genotype versus 29 (9%) of 322 who did not develop this complication (p=0.01, OR=5.48, 95% CI: 1.01-28.10). Accordingly, patients carrying the mutant T allele had an increased risk of developing severe nephropathy (p=0.016, OR=2.35, 95% CI: 1.09-5.07). Additionally, a significant increase of the TT genotype was observed in patients with persistent renal damage when compared with those patients without this complication (25% versus 8.6%, respectively; p=0.0035, OR=4.90, 95% CI: 1.26- 18.51). Moreover, renal sequelae were more common in patients carrying the mutant T allele (p=0.0076, OR=2.20, 95% CI: 1.17-4.14). CONCLUSIONS: Our results support that the IL1ß rs16944 polymorphism may be a potential marker of severe renal manifestations and renal sequelae in HSP.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Clin Exp Rheumatol. 2016 May-Jun;34(3 Suppl 97):84-8

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2016

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Autores/as

LÓPEZ-MEJÍAS, R

GENRE, F

REMUZGO-MARTÍNEZ, S

SEVILLA PÉREZ, B

ORTEGO-CENTENO, N

UBILLA, B

MIJARES, V

PINA, T

CALVO-RÍO, V

MIRANDA-FILLOY, JA

NAVAS PAREJO, A

ARGILA, D

SÁNCHEZ-PÉREZ, J

RUBIO, E

LUQUE, ML

BLANCA-MADRIGAL, JM

GALÍNDEZ-AGUIRREGOIKOA, E

MARTÍN, J