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Treatment of first-episode non-affective psychosis: a randomized comparison of aripiprazole, quetiapine and ziprasidone over 1 year

Abstract: RATIONALE: Discontinuation of antipsychotic treatment at early phases increases the risk of poor adherence to maintenance drug therapy. Differences among antipsychotics in terms of effectiveness may determine a good adherence to treatment. OBJECTIVES: The aim of this study is to compare the clinical effectiveness of aripiprazole, ziprasidone and quetiapine in the treatment of first-episode schizophrenia spectrum disorders at 1 year. METHOD: From October 2005 to January 2011 a prospective, randomized, open-label study was undertaken. Two hundred two first-episode drug-naïve patients were randomly assigned to aripiprazole (N?=?78), ziprasidone (N?=?62), or quetiapine (N?=?62) and followed up for 1 year. The primary effectiveness measure was all-cause of treatment discontinuation. In addition, an analysis based on intention-to-treat principle was conducted in the analysis for clinical efficacy. RESULTS: The overall dropout rate at 1 year was 13.37 %. The treatment discontinuation rate differed significantly between treatment groups (aripiprazole?=?43.6 %, ziprasidone?=?66.1 % and quetiapine?=?82.3 %) (? 2?=?22.545; p?

 Fuente: Psychopharmacology (2014) 231:357–366

Editorial: Springer

 Año de publicación: 2014

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1007/s00213-013-3241-3

ISSN: 0033-3158,1432-2072

Autores/as

ORTÍZ GARCÍA DE LA FOZ, VICTOR

IGNACIO MATA PASTOR

MARIA ROSA AYESA ARRIOLA

ELSA MARIA VALDIZAN RUIZ

OBDULIA MARTINEZ GARCIA

ROCIO PEREZ IGLESIAS