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Abstract: OBJECTIVES: The aim of this paper is to assess the clinical response to golimumab (GLM) in patients with non-infectious uveitis from a single centre that had previously been treated with other anti-TNF-a drugs.
METHODS: A retrospective chart review was carried out of patients with immune-mediated uveitis refractory to standard synthetic immunosuppressive drugs who were treated with GLM at Hospital Universitario Marqués de Valdecilla, Santander (Spain). Patients were included in this study if they had previously been treated with other anti-TNF-a drugs. A literature review of patients with immune-mediated uveitis undergoing GLM therapy was conducted.
RESULTS: Three patients (2 men and 1 woman) were included in this study. Two of them were refractory to other anti-TNF-a drugs. The median age of patients was 26 years (range 20-42). Uveitis was bilateral in two patients. The underlying diseases were uveitis associated with HLA-B27 and psoriasis in one case and sarcoidosis in the other two cases. Improvement of the main ocular parameters following GLM therapy was achieved in all cases. After a median follow-up of 3 (range 1-9) months using GLM therapy, none of the patients had experienced new relapses of uveitis. None of them had side effects during treatment with this drug. A literature review disclosed that our observations were in keeping with other reports that showed good response to GLM in 13 of 16 patients with immune-mediated uveitis refractory to other biologic agents.
CONCLUSIONS: Although the follow-up was too short in our series, GLM could be an effective and safe therapy for the management of patients with uveitis previously treated with other anti-TNF-a drugs.
Fuente: Clin Exp Rheumatol. 2014 Nov-Dec;32(6):864-8
Editorial: Clinical and Experimental Rheumatology
Año de publicación: 2014
Nº de páginas: 5
Tipo de publicación: Artículo de Revista
CALVO RIO, VANESA
HERA, DAVID DE LA
RICARDO BLANCO ALONSO
BELTRÁN CATALÁN, EMMA
JOAQUIN CAÑAL VILLANUEVA
JUAN ANTONIO VENTOSA AYARZA
JOSE MANUEL CIFRIAN MARTINEZ
ORTIZ SANJUÁN, FRANCISCO
JAVIER RUEDA GOTOR
MARIA CARMEN GONZALEZ VELA
MARCOS ANTONIO GONZALEZ LOPEZ
MIGUEL ANGEL GONZALEZ-GAY MANTECON