Estamos realizando la búsqueda. Por favor, espere...
Abstract: Background. Prognostic biomarkers of acute rejection (AR) in solid organ transplantation have been addressed in
multiple small retrospective studies, and there is a critical need for multicenter studies. Because of their tolerogenic
properties, regulatory T cells (Tregs) play an important role in transplant outcome.
Methods. In the present multicenter study, we have retrospectively examined different Treg subpopulations in an
independent cohort of kidney transplant patients within first year after kidney transplantation. All participating
centers used identical flow cytometry standard operating procedures.
Results. Seventy-five renal transplant patients were included, and six of them experienced an AR episode. The activated
Treg (aTreg) subpopulation (CD4+CD25highCD62L+CD45RO+) was increased in the AR group before transplantation,
and an aTreg percentage higher than 1.46% before kidney transplantation conferred an increased risk of
AR. The univariate logistic regression model achieved an area under the curve of 81.6%. By including recipient age
and thymoglobulin induction as variables in a multivariate logistic regression model, the prediction of AR improved
Fuente: Transplantation. 2014 Dec 15;98(11):1213-8
Editorial: Lippincott Williams & Wilkins
Fecha de publicación: 15/12/2014
Nº de páginas: 6
Tipo de publicación: Artículo de Revista
DAVID SAN SEGUNDO ARRIBAS
MUÑOZ CACHO, PEDRO
PAZ ARTAL, ESTELA
MORALES, JOSÉ MARÍA
MARIA DE LOS ANGELES DE COS COSSIO
MARCOS LOPEZ HOYOS