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Galectin-1 in stable liver transplant recipients

Abstract: Introduction. The achievement of a state of tolerance and minimization of the immunosuppressive load form part of the “Holy Grail” in solid organ transplantation. Galectin-1 recently has been described to be involved in the maintenance of a tolerant environment, but there is no evidence of its role in human liver transplantation. The aim of our study was to measure the serum levels of galectin-1 in stable liver transplant recipients. Methods. Serum levels of galectin-1 were determined in 30 stable liver transplant recipients who had been free of rejection episodes for at least 8 years. Fifteen patients with an acute rejection episode and 34 healthy subjects were used as the control group. Results. The concentrations of galectin-1 were significantly higher in stable liver transplant recipients compared with healthy subjects and with the acute rejection group. Conclusions. These preliminary results indicate that galectin-1 is upregulated in stable liver transplant recipients. Thus, our results extend the recent findings that galectin-1 may play an immune-suppressive role in liver transplantation. It remains to be established whether it might help to induce tolerance in liver transplantation.

Otras comunicaciones del congreso o articulos relacionados con autores/as de la Universidad de Cantabria

 Congreso: Congress of the Spanish Transplantation Society (3º : 2014 : Valencia)

Editorial: Elsevier

 Año de publicación: 2015

Nº de páginas: 4

Tipo de publicación: Comunicación a Congreso

 DOI: 10.1016/j.transproceed.2014.12.001

ISSN: 0041-1345,1873-2623

Autores/as

GARCÍA, M.J.

JURADO, F.

DAVID SAN SEGUNDO ARRIBAS

IRUZUBIETA, P.

LLERENA, S.

FERNANDO CASAFONT MORENCOS

MANUEL ANTONIO ARIAS RODRIGUEZ

PUENTE, Á.