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Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma–is it necessary?

Abstract: Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly (EBV+ DLBCL-e) is a molecularly distinct variant of DLBCL, characterized by a monoclonal B-cell proliferation that occurs in patients >50 years of age without a history or clinicopathologic evidence of immunodeficiency. However, patients with EBV+ DLBCL younger than 50-years-old also exist in Western countries. We evaluated the clinicopathologic, immunophenotypic and genetic features in Cacausian patients with EBV+ DLBCL who are =50 years of age and compared this patient group to patients who are >50 years. In patients who are =50 years, less frequent expression of BCL6 and a trend of more frequent expression of CD30 and pSTAT3 were found in patients with EBV+ DLBCL. In patients who are >50 years, common expression of CD30, p50, pSTAT3 and less frequent expression of BCL6 were observed. Older patients also more commonly had a poor performance status (ECOG=2). Comparing EBV+ DLBCL patients in =50 years versus >50 years, both groups had similar clinicopathologic, immunophenotypic and genetic features. Gene expression profiling, microRNA profiling and treatment outcome of the younger patients with EBV+ DLBCL was not distinctive from tumors in older patients. Based on our data, we suggest that the arbitrary age cutoff for EBV+ DLBCL is unnecessary and should be eliminated in the WHO lymphoma classification scheme.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Oncotarget. 2015 Jun 10; 6(16): 13933–13945.

Editorial: Impact Journals

 Fecha de publicación: 10/06/2015

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

ISSN: 1949-2553

Autores/as

OK, CHI YOUNG

YE, QING

LI, LING

MANYAM, GANIRAJU C.

DENG, LIJUAN

GOSWAMI, RASHMI R.

WANG, XIAOXIAO

SANTIAGO MONTES MORENO

VISCO, CARLO

TZANKOV, ALEXANDAR

DYBKAER, KAREN

ZHANG, LI

ABRAMSON, JEREMY

SOHANI, ALIYAH R.

CHIU, APRIL

ORAZI, ATTILIO

ZU, YOULI

BHAGAT, GOVIND

MIGUEL ANGEL PIRIS PINILLA

RICHARDS, KRISTY L.