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Abstract: Background Retinol-binding protein-4 (RBP4), an adipokine considered as an emerging cardiometabolic risk factor, is
increased in patients with moderate-to-severe psoriasis.
Objective In this study, we aimed to establish the effect of anti-TNF-a therapy on RBP4 levels in patients with moderate-
to-severe psoriasis. We also assessed if RBP4 levels correlate with metabolic syndrome features and disease severity
in these patients.
Methods Prospective study on a series of consecutive non-diabetic patients with moderate-to-severe psoriasis who
completed 6 months of therapy with adalimumab. Patients with kidney disease, hypertension or body mass
index ? 35 kg/m2 were excluded. Metabolic and clinical evaluation was performed at the onset of treatment (time 0) and
at month 6.
Results Twenty-nine patients were assessed. Statistically significant reduction (P = 0.0001) of RBP4 levels was
observed after 6 months of therapy (RBP4 at time 0: 55.7 21.4 lg/mL, vs. 35.6 29.9 lg/mL at month 6). No significant
correlation between basal RBP4 levels and metabolic syndrome features or disease severity was found. Nevertheless,
although RBP4 levels did not correlate with insulin resistance, a negative and significant correlation between RBP4
levels obtained after 6 months of adalimumab therapy and other metabolic syndrome features such as abdominal perimeter
and body mass index were observed. At that time, a negative and significant correlation between RBP4 levels and
disease activity scores and ultrasensitive CRP levels was also disclosed.
Conclusion Our results support an influence of the anti-TNF-a blockade on RBP4 serum levels. This finding is of
potential relevance due to increased risk of cardiovascular disease in patients with psoriasis.
Fuente: J Eur Acad Dermatol Venereol. 2016 Jan;30(1):92-5
Editorial: Blackwell Publishing Ltd
Año de publicación: 2016
Nº de páginas: 4
Tipo de publicación: Artículo de Revista
PINA MURCIA, TRINITARIO
LÓPEZ MEJÍAS, RAQUEL
SUSANA ARMESTO ALONSO
BEGOÑA UBILLA GARCIA
VERONICA MIJARES DIAZ
TRINIDAD DIERSSEN SOTOS
ALFONSO FERNANDO CORRALES MARTINEZ
MARCOS ANTONIO GONZALEZ LOPEZ
MARIA CARMEN GONZALEZ VELA
RICARDO BLANCO ALONSO
FRANCISCO JAVIER LLORCA DIAZ
MIGUEL ANGEL GONZALEZ-GAY MANTECON