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Comparative Genomics of the Conjugation Region of F-like Plasmids: Five Shades of F

Abstract: The F plasmid is the foremost representative of a large group of conjugative plasmids, prevalent in Escherichia coli, and widely distributed among the Enterobacteriaceae. These plasmids are of clinical relevance, given their frequent association with virulence determinants, colicins, and antibiotic resistance genes. Originally defined by their sensitivity to certain male-specific phages, IncF plasmids share a conserved conjugative system and regulatory circuits. In order to determine whether the genetic architecture and regulation circuits are preserved among these plasmids, we analyzed the natural diversity of F-like plasmids. Using the relaxase as a phylogenetic marker, we identified 256 plasmids belonging to the IncF/ MOBF12group, present as complete DNA sequences in the NCBI database. By comparative genomics, we identified five major groups of F-like plasmids. Each shows a particular operon structure and alternate regulatory systems. Results show that the IncF/MOBF12 conjugation gene cluster conforms a diverse and ancient group, which evolved alternative regulatory schemes in its adaptation to different environments and bacterial hosts.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Front Mol Biosci. 2016 Nov 10;3:71

Editorial: Lausanne : Frontiers Media

 Año de publicación: 2016

Nº de páginas: 14

Tipo de publicación: Artículo de Revista

 DOI: 10.3389/fmolb.2016.00071

ISSN: 2296-889X

Proyecto español: BFU2014-55534-C2-1-P and BFU2014-62190-EXP from the Spanish Ministry of Economy and Competitiveness and 612146/FP7-ICT-2013-10 from the European Seventh Framework Programme.