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Anti-tumor necrosis factor-alpha therapy improves endothelial function and arterial stiffness in patients with moderate to severe psoriasis: A 6-month prospective study

Abstract: The aim of the present study was to determine if the use of the anti-tumor necrosis factor (TNF)-? monoclonal antibody adalimumab could improve endothelial function and arterial stiffness in patients with moderate to severe psoriasis. This was a prospective study on a series of consecutive patients with moderate to severe psoriasis who completed 6 months of therapy with adalimumab. Patients with history of cardiovascular events, diabetes mellitus, kidney disease, hypertension or body mass index of 35 kg/m2 or more were excluded. Assessment of endothelial function by brachial artery reactivity measuring flow-mediated endothelial dependent vasodilatation (FMD%), and carotid arterial stiffness by pulse wave velocity (PWV) was performed at the onset of treatment (time 0) and at month 6. Twenty-nine patients were studied. Anti-TNF-? adalimumab therapy yielded a significant improvement of endothelial function. The mean ± standard deviation (SD) FMD% values increased from 6.19 ± 2.44% at the onset of adalimumab to 7.46 ± 2.43% after 6 months of treatment with this biologic agent (P = 0.008). Likewise, following the use of adalimumab, PWV levels decreased from 6.28 ± 1.04 m/s at the onset of adalimumab to 5.69 ± 1.31 m/s at 6 months (P = 0.03). In conclusion, patients with moderate to severe psoriasis exhibit improvement of endothelial function and arterial stiffness following anti-TNF-? therapy. These findings are of potential relevance due to increased risk of cardiovascular disease in patients with severe psoriasis.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: J Dermatol. 2016 Nov;43(11):1267-1272

Editorial: Wiley-Blackwell

 Año de publicación: 2016

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/1346-8138.13398

ISSN: 0385-2407,1346-8138

Autores/as

PINA, TRINITARIO

CORRALES, ALFONSO

LÓPEZ MEJÍAS, RAQUEL

UBILLA, BEGOÑA

RREMUZGO MARTÍNEZ, SARA

BLANCO, RICARDO