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Menstrual and Reproductive Factors and Risk of Gastric and Colorectal Cancer in Spain

Abstract: BACKGROUND: Sex hormones play a role in gastric cancer and colorectal cancer etiology, however, epidemiological evidence is inconsistent. This study examines the influence of menstrual and reproductive factors over the risk of both tumors. METHODS: In this case-control study 128 women with gastric cancer and 1293 controls, as well as 562 female and colorectal cancer cases and 1605 controls were recruited in 9 and 11 Spanish provinces, respectively. Population controls were frequency matched to cases by age and province. Demographic and reproductive data were directly surveyed by trained staff. The association with gastric, colon and rectal cancer was assessed using logistic and multinomial mixed regression models. RESULTS: Our results show an inverse association of age at first birth with gastric cancer risk (five-year trend: OR = 0.69; p-value = 0.006). Ever users of hormonal contraception presented a decreased risk of gastric (OR = 0.42; 95%CI = 0.26-0.69), colon (OR = 0.64; 95%CI = 0.48-0.86) and rectal cancer (OR = 0.61; 95%CI = 0.43-0.88). Postmenopausal women who used hormone replacement therapy showed a decreased risk of colon and rectal tumors. A significant interaction of educational level with parity and months of first child lactation was also observed. CONCLUSION: These findings suggest a protective role of exogenous hormones in gastric and colorectal cancer risk. The role of endogenous hormones remains unclear.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: PLoS One. 2016 Oct 24;11(10):e0164620

Editorial: Public Library of Science

 Año de publicación: 2016

Nº de páginas: 16

Tipo de publicación: Artículo de Revista

 DOI: 10.1371/journal.pone.0164620

ISSN: 1932-6203

Autores/as

LOPE, VIRGINIA

FERNÁNDEZ DE LARREA, NEREA

PÉREZ GÓMEZ, BEATRIZ

MARTÍN, VICENTE

MORENO, VICTOR

COSTAS, LAURA

LONGO, FEDERICO

JOSE JUAN JIMENEZ MOLEON

PEIRÓ PÉREZ, ROSANA

ALTZIBAR, JONE M

TARDÓN, ADONINA

ALGUACIL, JUAN

NAVARRO, CARMEN

SIERRA, ANGELES

VEGA, ANA BELÉN

VILLAFAÑE, AMAYA

CASTAÑO VINYAL, GEMMA

KOGEVINAS, MANOLIS

POLLÁN, MARINA

ARAGONÉS, NURIA