Sex hormones play a role in gastric cancer and colorectal cancer etiology, however, epidemiological evidence is inconsistent. This study examines the influence of menstrual and reproductive factors over the risk of both tumors.
In this case-control study 128 women with gastric cancer and 1293 controls, as well as 562 female and colorectal cancer cases and 1605 controls were recruited in 9 and 11 Spanish provinces, respectively. Population controls were frequency matched to cases by age and province. Demographic and reproductive data were directly surveyed by trained staff. The association with gastric, colon and rectal cancer was assessed using logistic and multinomial mixed regression models.
Our results show an inverse association of age at first birth with gastric cancer risk (five-year trend: OR = 0.69; p-value = 0.006). Ever users of hormonal contraception presented a decreased risk of gastric (OR = 0.42; 95%CI = 0.26-0.69), colon (OR = 0.64; 95%CI = 0.48-0.86) and rectal cancer (OR = 0.61; 95%CI = 0.43-0.88). Postmenopausal women who used hormone replacement therapy showed a decreased risk of colon and rectal tumors. A significant interaction of educational level with parity and months of first child lactation was also observed.
These findings suggest a protective role of exogenous hormones in gastric and colorectal cancer risk. The role of endogenous hormones remains unclear.
Fuente: PLoS One. 2016 Oct 24;11(10):e0164620
Editorial: Public Library of Science
Año de publicación: 2016
Nº de páginas: 16
Tipo de publicación: Artículo de Revista
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FERNÁNDEZ DE LARREA, NEREA
PÉREZ GÓMEZ, BEATRIZ
JOSE JUAN JIMENEZ MOLEON
FRANCISCO JAVIER LLORCA DIAZ
PEIRÓ PÉREZ, ROSANA
ALTZIBAR, JONE M
VEGA, ANA BELÉN
CASTAÑO VINYAL, GEMMA