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Expression of osteoprotegerin and its ligands, RANKL and TRAIL, in rheumatoid arthritis

Abstract: Osteoprotegerin (OPG), receptor activator of nuclear factor-?B ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) have been involved in rheumatoid arthritis (RA) pathophysiology. In this study, we assessed messenger RNA (mRNA) expression of these molecules by qPCR in peripheral blood from 26 patients with RA (12 of them with ischemic heart disease -IHD) and 10 healthy controls. Correlation coefficients between OPG, RANKL and TRAIL expression levels in RA patients and their clinical and demographic characteristics were also evaluated. Whereas OPG and OPG/TRAIL ratio expression were significantly increased in RA patients compared to controls (fold change?=?1.79, p?=?0.013 and 2.07, p?=?0.030, respectively), RANKL/OPG ratio was significantly decreased (fold change?=?0.50, p?=?0.020). No significant differences were found between patients and controls in RANKL and TRAIL expression. Interestingly, TRAIL expression was significantly higher in RA patients with IHD compared to those without IHD (fold change?=?1.46, p?=?0.033). Moreover, biologic disease-modifying antirheumatic drugs (DMARDs) significantly decreased RANKL expression in RA patients (p?=?0.016). Our study supports an important role of OPG and TRAIL in RA. Furthermore, it highlights an effect of biologic DMARDs in the modulation of RANKL.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Sci Rep. 2016 Jul 12;6:29713

Editorial: Nature Publishing Group

 Año de publicación: 2016

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/srep29713

ISSN: 2045-2322

Autores/as

REMUZGO MARTÍNEZ, SARA

GENRE, FERNANDA

LÓPEZ MEJÍAS, RAQUEL

UBILLA, BEGOÑA

MIJARES, VERÓNICA

PINA, TRINITARIO

CORRALES, ALFONSO

MARTÍN, JAVIER