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The effect of biologic therapy different from infliximab or adalimumab in patients with refractory uveitis due to Behçet?s disease: results of a multicentre open-label study

Abstract: Objective. To assess the efficacy of other biologic therapies, different from IFX and ADA, in patients with Behçet?s disease uveitis (BU). Methods. Multicentre study of 124 patients with BU refractory to at least one standard immunosuppressive agent that required IFX or ADA therapy. Patients who had to be switched to another biologic agent due to inefficacy or intolerance to IFX or ADA or patient´s decision were assessed. The main outcome measures were the degree of anterior and posterior chamber inflammation and macular thickness. Results. Seven (5.6%) of 124 cases (4 women/3 men; mean age, 43 (range 28-67) years; 12 affected eyes) were studied. Five of them had been initially treated with ADA and 2 with IFX. The other biologic agents used were golimumab (n=4), tocilizumab (n=2) and rituximab (n=1). The ocular pattern was panuveitis (n=4) or posterior uveitis (n=3). Uveitis was bilateral in 5 patients (71.4%). At baseline, anterior chamber and vitreous inflammation were present in 6 (50%) and 7 (58.3%) of the eyes. All the patients (12 eyes) had macular thickening (OCT>250?m) and 4 of them (7 eyes), cystoid macular oedema (OCT>300 ?m). Besides reduction anterior chamber and vitreous inflammation, we observed a reduction of OCT values, from 330.4±58.5 ?m at the onset of the biological agent to 273±50 ?m at month 12 (p=0.06). Six patients achieved a complete remission of uveitis. Conclusion. The vast majority of patients with BU refractory to standard immunosuppressive drugs are successfully controlled with ADA and/or IFX. Other biologic agents also appear to be useful.

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 Fuente: Clin Exp Rheumatol 2016; 34 (Suppl. 102): S34-S40

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2016

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Autores/as

SANTOS GÓMEZ, M.

CALVO RÍO, V.

RICARDO BLANCO ALONSO

BELTRÁN, E.

MESQUIDA, M.

ADÁN, A.

CORDERO COMA, M.

GARCÍA APARICIO, A.M.

VALLS PASCUAL, E.

MARTÍNEZ COSTA, L.

HERNÁNDEZ, M.V.

HERNÁNDEZ GARFELLA, M.

PINA MURCIA, TRINITARIO

PALMOU FONTANA, N.

JAVIER LORICERA GARCIA