Abstract: Background: Chronic inflammatory diseases have been associated with increased prevalence of
subclinical atherosclerosis. Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving
Objective: We sought to investigate the potential association between HS and subclinical atherosclerosis.
Methods: This study included 68 patients with HS and 136 age- and sex-matched healthy control subjects.
Patients with history of cardiovascular events, diabetes mellitus, chronic kidney disease, or another
concomitant inflammatory condition were excluded. Carotid intima-media thickness and carotid plaques
were measured by carotid ultrasonography. Adjustments were made for age, sex, and traditional
cardiovascular risk factors.
Results: Patients had greater carotid intima-media thickness values than control subjects (0.615 6 0.097 vs
0.578 6 0.098 mm; P = .012). Carotid plaques were also more frequent in patients than in control subjects
(30.9% vs 22.1%). In the multivariable regression model adjusted for age, sex, and traditional cardiovascular
risk factors, HS was significantly related to the presence of carotid plaques (odds ratio 2.99, 95% confidence
interval 1.26-7.13; P = .013).
Limitations: Causality could not be assessed.
Conclusions: These results indicate an increased frequency of subclinical atherosclerosis in patients with
HS. Accordingly, HS should be considered a disease associated with potentially increased cardiovascular
Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria
Fuente: Journal of the American Academy of Dermatology Volume 75, Issue 2, August 2016, Pages 329-335
Año de publicación: 2016
Nº de páginas: 7
Tipo de publicación: Artículo de Revista