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Our objective was to examine associations of traditional and non-traditional cardiovascular risk factors with relative
leukocyte telomere length and confounder adjusted relationships of relative telomere length with endothelial activation
and carotid atherosclerosis in black and white African patients with rheumatoid arthritis (RA).
Relative telomere length of leukocyte DNA in whole blood was determined using quantitative RT-PCR in 205 (101 black)
African patients with RA.
In demographic characteristic adjusted analysis, relative telomere length tended to be larger in black compared to
white patients (median (IQR)=0.54 (0.42-0.54) and 0.48 (0.37-0.60) (p=0.07), respectively). In black patients, waist
circumference, systolic, diastolic and mean blood pressure were associated with relative telomere length (? (SE)=-0.00270
(0.00114) (p=0.02), -0.00185 (0.00060) (p=0.003), -0.00243 (0.00112) (p=0.03) and -0.00225 (0.00075) (p=0.003),
respectively); in white patients, age, anti-cyclic citrullinated antibody positivity, biologic agent use, a cholesterol-HDL
cholesterol ratio of >4 and the number of major traditional risk factors were related to relative telomere length (? (SE)
=-0.00242 (0.00113) (p=0.03), 0.06629 (0.03374) (p=0.05), -0.09321 (0.04310) (p=0.03), 0.08225 (0.03420) (p=0.02)
and 0.04046 (0.01719) (p=0.02), respectively). One SD increase in relative telomere length was associated with carotid
plaque (OR (95% CI)=1.65 (0.99-2.75) (p=0.05)) and vascular cell adhesion molecule-1 concentrations (? (SE)=-0.05031
(0.02480) (p=0.04)) in black and white patients, respectively.
This study disclosed paradoxically direct relationships between relative telomere length and cardiovascular risk factors
in white and atherosclerosis in black African RA patients. The role of relative telomere length in cardiovascular risk and
its stratification in RA requires longitudinal investigation.
Fuente: Clinical and Experimental Rheumatology 2016; 34: 864-871
Editorial: Clinical and Experimental Rheumatology
Año de publicación: 2016
Nº de páginas: 8
Tipo de publicación: Artículo de Revista
MIGUEL ANGEL GONZALEZ-GAY MANTECON