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Abstract: Objective. To determine if cutaneous
vasculitis (CV) associated with severe
infection has some histopathologic
findings that may help us to differentiate
patients with this condition from
other patients with CV.
Methods. We reviewed the skin biopsy
specimens of patients with leukocytoclastic
CV associated with a severe
bacterial infection. Histopathologic
findings of these patients were compared
with those observed in leukocytoclastic
CV secondary to other causes.
Biopsy-proven leukocytoclastic CV
were stratified as follows: group a): CV
associated with severe underlying bacterial
infection; group b): CV without
severe bacterial infection but with systemic
involvement; group c): CV without
systemic involvement. Slides were
reviewed by expert pathologists that
were blind to the clinical information.
The severity of vascular lesions was
measured according to a semiquantitative
scale (Hodge index). A comparative
study between group a) and the
other groups was conducted.
Results. group a) included 12 patients
(2 women/10 men), mean age±
SD 56±15 years; group b) 21 patients
(10 women/11 men), 52±18 years; and
group c) 19 patients (12 women/7 men),
59±24 years. Presence of neutrophilia
was significantly increased in biopsies
from group a) when compared with
the other two groups. Also, a trend to
higher frequency of pustular dermatosis
was found in patients from group a).
Hodge index, degree of inflammatory
infiltrate and deep arterioles involvement
were similar in all groups.
Conclusion. Neutrophilia is common
in skin biopsies of patients with CV
associated with severe bacterial infecinfection.
No other histopathological findings
help us to establish the presence
of a severe underlying infection.
Fuente: Clin Exp Rheumatol 2016; 34 (Suppl. 97): S93-S97
Editorial: Clinical and Experimental Rheumatology
Año de publicación: 2016
Nº de páginas: 5
Tipo de publicación: Artículo de Revista
JAVIER LORICERA GARCIA
MARIA CARMEN GONZALEZ VELA
RICARDO BLANCO ALONSO
JOSE LUIS HERNANDEZ HERNANDEZ
SUSANA ARMESTO ALONSO
MARCOS ANTONIO GONZALEZ LOPEZ
CALVO RÍO, VANESA
ORTIZ SANJUÁN, F.
JOSE FERNANDO VAL BERNAL
MARIA SANDRA HERMANA RAMIREZ
ARANTZA ONAINDIA PEREZ
MIGUEL ANGEL GONZALEZ-GAY MANTECON