Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Histopathologic differences between cutaneous vasculitis associated with severe bacterial infection and cutaneous vasculitis secondary to other causes: a study of 52 patients

Abstract: Objective. To determine if cutaneous vasculitis (CV) associated with severe infection has some histopathologic findings that may help us to differentiate patients with this condition from other patients with CV. Methods. We reviewed the skin biopsy specimens of patients with leukocytoclastic CV associated with a severe bacterial infection. Histopathologic findings of these patients were compared with those observed in leukocytoclastic CV secondary to other causes. Biopsy-proven leukocytoclastic CV were stratified as follows: group a): CV associated with severe underlying bacterial infection; group b): CV without severe bacterial infection but with systemic involvement; group c): CV without systemic involvement. Slides were reviewed by expert pathologists that were blind to the clinical information. The severity of vascular lesions was measured according to a semiquantitative scale (Hodge index). A comparative study between group a) and the other groups was conducted. Results. group a) included 12 patients (2 women/10 men), mean age± SD 56±15 years; group b) 21 patients (10 women/11 men), 52±18 years; and group c) 19 patients (12 women/7 men), 59±24 years. Presence of neutrophilia was significantly increased in biopsies from group a) when compared with the other two groups. Also, a trend to higher frequency of pustular dermatosis was found in patients from group a). Hodge index, degree of inflammatory infiltrate and deep arterioles involvement were similar in all groups. Conclusion. Neutrophilia is common in skin biopsies of patients with CV associated with severe bacterial infecinfection. No other histopathological findings help us to establish the presence of a severe underlying infection.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Clin Exp Rheumatol 2016; 34 (Suppl. 97): S93-S97

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2016

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Autores/as

JAVIER LORICERA GARCIA

RICARDO BLANCO ALONSO

CALVO RÍO, VANESA

ORTIZ SANJUÁN, F.

JOSE FERNANDO VAL BERNAL

MARIA SANDRA HERMANA RAMIREZ

ARANTZA ONAINDIA PEREZ