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 Detalle_Publicacion

Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project

Abstract: Background Plasma concentrations of lipoprotein (a) (Lp(a)), a lipoprotein with atherogenic and thrombogenic properties, have a strong genetic basis, although high concentrations of Lp(a) have also been reported in the context of inflammation, as in rheumatoid arthritis (RA). Few studies evaluate the impact of biologic therapies (BT) on Lp(a) in RA, taking into account that with these new therapies a better control of inflammation is achieved. Objective The aim of the study was to evaluate the plasma concentrations of Lp(a) in Spanish RA patients on BT attending rheumatology outpatient clinics. Methods Baseline analysis of the CARdiovascular in rheuMAtology project, a 10-year prospective study, evaluating the risk of cardiovascular events in RA and other forms of inflammatory arthritis. RA patients were classified according to treatment: no biologic, anti-tumor necrosis factor, anti-interleukin-6 receptor tocilizumab (TCZ), and other biologic (rituximab or abatacept). A model of linear multivariate regression was built in which the dependent variable was Lp(a) concentration and the explanatory variable was BT. The model was adjusted for confounding factors. Results Seven hundred and seventy-five RA patients were analyzed. Plasma concentrations of total cholesterol and triglyceride were significantly higher in TCZ-treated patients. Nevertheless, no significant difference in the atherogenic index between TCZ-treated patients and patients without BT was found. After adjusting for confounding factors, patients with BT had lower concentrations of Lp(a) than those without BT; however, only TCZ-treated patients achieved statistically significant differences (?: ?0.303, 95% confidence interval: ?0.558 to ?0.047; P = .02). Conclusions RA patients treated with TCZ show lower plasma concentrations of Lp(a) compared with patients without BT.

 Fuente: Journal of Clinical Lipidology (2017), Volume 11, Issue 3, May-June 2017, Pages 749-756

Editorial: Elsevier

 Año de publicación: 2017

Nº de páginas: 30

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.jacl.2017.02.018

ISSN: 1933-2874,1876-4789

Autores/as

GARCÍA GÓMEZ, CARMEN

MARTÍN MARTÍNEZ, MARIA A.

CASTAÑEDA, SANTOS

SANCHEZ ALONSO, FERNANDO

URIARTE ECENARRO, MIREN

GONZÁLEZ JUANATEY, CARLOS

ROMERA BAURES, MONTSERRAT

SANTOS REY, JOSÉ

PINTO TASENDE, JOSÉ ANTONIO

QUESADA MASACHS, ESTEFANÍA

TORNERO MOLINA, JESÚS

MARTÍNEZ GONZÁLEZ, OLGA

COBO IBÁÑEZ, TATIANA

CHAMIZO CARMONA, EUGENIO

MANRIQUE ARIJA, SARA

FÁBREGAS CANALES, DOLORES

DÍAZ GONZÁLEZ, FEDERICO