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A Biomimetic Escape Strategy for Cytoplasm Invasion by Synthetic Particles

Abstract: The translocation of nanomaterials or complex delivery systems into the cytosol is a major challenge in nanobiotechnology. After receptor-mediated endocytosis, most nanomaterials are sequestered and undergo degradation, therapy inactivation, or exocytosis. Herein we explore a novel surface particle coating made of adsorbed carbon nanotubes that provides coated materials with new properties that reproduce the viral cell-invasive mechanisms, namely, receptor-mediated endocytosis, endolysosomal escape, and cytosolic particle release preserving cell viability. This novel biomimetic coating design will enable the intracytoplasmic delivery of many different functional materials endowed with therapeutic, magnetic, optical, or catalytic functionalities, thus opening the door to a wide array of chemical and physical processes within the cytosolic or nuclear domains, and supporting new developments in the biotechnological, pharmaceutical, and biomedical industries.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Angewandte Chemie Volume 56, Issue 44 October 23, 2017 Pages 13736-13740

Editorial: Wiley

 Fecha de publicación: 23/10/2017

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1002/anie.201707769

ISSN: 1521-3773,1433-7851

Autores/as

NEREA ITURRIOZ RODRIGUEZ

GONZÁLEZ DOMÍNGUEZ, E.

ELOISA GONZALEZ LAVADO

MARÍN CABA, L.

VAZ, B.

PÉREZ LORENZO, M.

CORREA DUARTE, M.A.