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Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

Abstract: Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Sci Rep. 2016 Aug 18;6:31979

Editorial: Nature Publishing Group

 Año de publicación: 2016

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/srep31979

ISSN: 2045-2322

Url de la publicación: https://doi.org/10.1038/srep31979

Autores/as

LÓPEZ MEJÍAS, R.

REMUZGO MARTÍNEZ, S.

GONZÁLEZ JUANATEY, C.

ROBUSTILLO VILLARINO, M.

VICENTE, E.

MIRANDA FILLOY, JA.

MAGRO, C.

TEJERA SEGURA, B.

RAMÍREZ HUARANGA, MA.

PINA, T.

BLANCO, R.

ALEGRE SANCHO, JJ.

RAYA, E.

MIJARES, V.

UBILLA GARCÍA, BEGOÑA

MÍNGUEZ SÁNCHEZ, MD.

GÓMEZ VAQUERO, C.

BALSA, A.

PASCUAL SALCEDO, D.

LÓPEZ LONGO, FJ.

CARREIRA, P.

GONZÁLEZ ALVARO, I.

RODRÍGUEZ RODRÍGUEZ, L.

FERNÁNDEZ GUTIÉRREZ, B.

FERRAZ AMARO, I.

CASTAÑEDA, S.

GENRE, FERNANDA