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Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study

Abstract: BACKGROUND: Helicobacter pylori infection is one of the main risk factors for non-cardia gastric cancer. However, only a minority of infected persons develop the disease. This study aims at identifying H. pylori related serological biomarkers of risk for gastric cancer. METHODS: Incident gastric cancer cases and population controls (age, sex and region frequency-matched) from the MCC-Spain multicase-control Study were included. Seroreactivities against 16H. pylori proteins were determined using multiplex serology. Infection was defined as seropositivity against?4 proteins. Relation of serological results to non-cardia and cardia gastric cancer was assessed using multivariable mixed logistic regression and principal components analysis. RESULTS: Seroprevalence was 88% among 2071 controls, 95% among 202 non-cardia gastric cancer cases (OR=1.9 (95% CI: 1.0-3.6)) and 85% among 62 cardia cancer cases (OR=0.5 (95% CI: 0.3-1.1)). In infected subjects, seropositivity for UreA, HP231, NapA and Cag? was associated with lower non-cardia gastric cancer risk, while seropositivity for CagA and VacA was associated with higher risk. Seropositivity for CagA and seronegativity for Cag? maintained the association after additional adjustment by serostatus of significant proteins. We identified two antibody reactivity patterns: the "virulent-pattern", related to a threefold higher risk of non-cardia gastric cancer and the "non-virulent pattern", related to a 60% decreased risk (4th vs. first quartile). CONCLUSIONS: In our population, people seropositive for H. pylori were characterized by two patterns of antibody reactivity against H. pylori proteins: 1) Combined high seroreactivity against several proteins, associated with a lower non-cardia gastric cancer risk, and 2) High seroreactivity against CagA and VacA, associated with an increased risk.

 Fuente: Cancer Epidemiol. 2017 Oct;50(Pt A):76-84

Editorial: Elsevier

 Año de publicación: 2017

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.canep.2017.08.002

ISSN: 1877-7821,1877-783X

Autores/as

FERNÁNDEZ DE LARREA BAZ, NEREA

PÉREZ GÓMEZ, BEATRIZ

MICHEL, ANGELIKA

ROMERO, BEATRIZ

LOPE, VIRGINIA

PAWLITA, MICHAEL

FERNÁNDEZ VILLA, TANIA

MORENO, VICTOR

MARTÍN, VICENTE

WILLHAUCK FLECKENSTEIN, MARTINA

LÓPEZ ABENTE, GONZALO

CASTILLA, JESÚS

FERNÁNDEZ TARDÓN, GUILLERMO

JIMÉNEZ MOLEÓN, JOSÉ JUAN

NAVARRO, CARMEN

CASTAÑO VINYALS, GEMMA

KOGEVINAS, MANOLIS